alexa Promazine Hydrochloride/PLGA Biodegradable Nanoparticles Formulation and Release
ISSN: 2161-0398

Journal of Physical Chemistry & Biophysics
Open Access

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Research Article

Promazine Hydrochloride/PLGA Biodegradable Nanoparticles Formulation and Release

Urszula Domańska1,2* and Mohammed Halayqa1
1Warsaw University of Technology, Faculty of Chemistry, Department of Physical Chemistry, Warsaw, Poland
2Thermodynamic Research Unit, School of Engineering, University of KwaZulu-Natal, Howard College Campus, Durban 4041, South Africa
Corresponding Author : Urszula Domanska
Warsaw University of Technology
Faculty of Chemistry, Department of Physical Chemistry
Noakowskiego 3, 00-664 Warsaw, Poland
Tel: +48 22 6213115
Fax: +48 22 6282741
E-mail: [email protected]
Received April 4, 2014; Accepted March 1, 2014; Published May 03, 2014
Citation: Domanska U, HalayqaM (2014) Promazine Hydrochloride/PLGA Biodegradable Nanoparticles Formulation and Release. J Phys Chem Biophys 4:143. doi:10.4172/2161-0398.1000143
Copyright: © 2014 Domanska U, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

This study reports the development of a novel formulation of a polymeric nanoparticls (NPs) with the drug Promazine hydrochloride (PRO), a hydrophobic molecule, dispersed in biodegradable polymeric matrix of poly (DLlactide- co-glycolide) (PLGA) by using emulsion-solvent evaporation method at the temperature T = 298.15 K. Spherical NPs with controlled size were designed. PRO was capsulated into nanoparticles with theoretical drug loading (TDL) varying from 10 to 30% (w/w). The effects of TDL, of poly(vinyl alcohol) (PVA) concentration, of PLGA concentration in organic phase, the effect of power of sonication and of pH of aqueous phase were studied. After lyophilization of PRO-loaded nanoparticles, the average size, Zeta potential, and polydispersity index at TDL 30% were 350 ± 22 nm, −18.7 ± 2.0 mV, and 0.18 ± 0.04, respectively (at TDL 30%, PLGA content 1.3 % w/v and pH = 9). The maximum drug encapsulation efficiency and drug loading capacity were 32.74 ± 0.54% (w/w) and 19.13 ± 0.38 %, respectively (at TDL 30%, PLGA content 1.3% w/v and pH = 9). Scanning electron microscopy studies showed spherical and smoth shape of drug-loaded nanoparticles. Solid lyophilized NPs were evaluated for in vitro release in phosphate–buffered saline (pH = 7.4) by using dialysis bags. Parameters for the release process showed that both the initial PLGA content and energy of sonication have no significant influence on PRO release from NPs.

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