alexa Prominent Non-Motor Symptoms in Patients with Parkinson?s Disease and Pain
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

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Research Article

Prominent Non-Motor Symptoms in Patients with Parkinson?s Disease and Pain

Cheng-Jie Mao1,2, Ju-Ping Chen3, Xiao-Yi Zhang1, Jie Li1,2, Kang-Ping Xiong1,2, Yi Chen1, Si-Jiao Li1, Wei-Dong Hu1, Li-Fang Hu2 and Chun-Feng Liu1,2*

1Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou, China

2Institute of Neuroscience, Soochow University, Suzhou, China

3Department of Neurology, Hospital of Changshu Traditional Chinese Medicine, East Huanghe Road, Changshu, China

Corresponding Author:
Chun-Feng Liu
Department of Neurology
the Second Affiliated Hospital of Soochow University
1055, Sanxiang Road, Suzhou, China
Tel: +86 512 67783307
Fax: +86 512 68284303
E-mail: [email protected]

Received date: April 17, 2014; Accepted date: May 24, 2014; Published date: May 30, 2014

Citation: Mao CJ, Chen JP, Zhang XY, Li J, Xiong KP, Chen Y, Li SJ, Hu WD, et al., (2014) Prominent Non-Motor Symptoms in Patients with Parkinson’s Disease and Pain. J Neurol Neurophysiol 5:208. doi:10.4172/2155-9562.1000208

Copyright: © 2014 Mao JC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Sensory disorders including pain and other non-motor symptoms occur frequently in patients with Parkinson’s
disease (PD). Studies on the correlation between pain and non-motor symptoms such as depression and sleep
disorders are relatively more, so further investigations of the correlation between pain and other non-motor
symptoms of PD are needed. A total of 142 patients with PD with or without pain were included in the study. PD
severity was evaluated using the Unified Parkinson’s Disease Rating Scale (UPDRS) and the Hoehn and Yahr (H/Y)
stage scale. Pain severity was analyzed using the Visual Analog Scale (VAS) and the Brief Pain Inventory (BPI).
The Hamilton Rating Scale for Depression (HRSD; 24 items), Montreal Cognitive Assessment Beijing Version
(MoCA), and non-motor questionnaire NMSQT) measured symptoms of depression, cognitive function, and nonmotor
symptoms. The incidence of pain was 47.9% in patients with PD, most of whom had moderate pain levels.
Patients with pain showed higher HRSD, UPDRS, H/Y, and NMSQT scores and lower MoCA scores compared to
patients without pain. HRSD and NMSQT scores were closely related with pain (p<0.001). The incidence of pain is
higher in patients with PD in pain than in those without pain. Musculoskeletal pain was commonly seen in patients
with PD. Compared to controls and patients with PD without pain, non-motor symptoms were more prominent in
patients with pain.


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