alexa Properties of Uterine Natural Killer Cells in Human Pregnancy, Major Receptors Involved, and Routes of Trophoblast Invasion
ISSN: 2168-9431

Single Cell Biology
Open Access

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Review Article

Properties of Uterine Natural Killer Cells in Human Pregnancy, Major Receptors Involved, and Routes of Trophoblast Invasion

Tarek S Beytamouni and Esther Ghanem*
Department of Sciences, Faculty of Natural and Applied Sciences, Notre Dame University, 72 Lebanon
*Corresponding Author : Ghanem E
Department of Sciences
Faculty of Natural and Applied Sciences
Notre Dame University, 72 Lebanon
Tel: + 961 9218950-ext.2738
E-mail: [email protected]
Received: February 09, 2016; Accepted: March 07, 2016; Published: March 09, 2016
Citation: Beytamouni TS, Ghanem E (2016) Properties of Uterine Natural Killer Cells in Human Pregnancy, Major Receptors Involved, and Routes of Trophoblast Invasion. Single Cell Biol 5:133. doi:10.4172/2168-9431.1000133
Copyright: © 2016 Beytamouni TS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Suppression of the maternal immune system to tolerate the fetal alloantigens during implantation translates into an immunological paradox. The initial process of implantation is marked by the migration of interstitial extravillous trophoblast (EVT) into the endometrial wall and is assisted by maternal uterine natural killer (uNK) cells. Any impairment in uNK assistance can ultimately lead to loss of pregnancy. In this review, we discuss current information regarding the role of uNK cells in healthy human pregnancy and their importance in sustaining a controlled invasion of the endometrium by EVT.

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