Prophylactic Effectiveness of Budesonide Inhalation in Reducing Postoperative Throat ComplaintsYan-Qing Chen1,2, Jia-Dong Wang1,2* and Jie Xiao3
- *Corresponding Author:
- Jia-Dong Wang
Department of Otolaryngology-Head & Neck Surgery, Building 7
Renji Hospital, Dongfang Road, Shanghai 200127, China
Tel: +8621 68383769
E-mail: [email protected]
Received date: July 09, 2012; Accepted date: July 23, 2012; Published date: July 28, 2012
Citation: Chen YQ, Wang JD, Xiao J (2012) Prophylactic Effectiveness of Budesonide Inhalation in Reducing Postoperative Throat Complaints. J Anesth Clin Res 3:225. doi: 10.4172/2155-6148.1000225
Copyright: © 2012 Chen YQ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: To evaluate the efficacy of budesonide suspension inhalation in reducing the incidence and severity of postoperative sore throat (POST) and hoarseness induced by tracheal intubation.
Methods: 120 patients scheduled for thyroid surgery with general anaesthesia were randomized into 3 groups. Group A received 200 mcg budesonide inhalation suspension (BIS) 10 min prior to the tracheal intubation and received the same treatment 6 h and 24 h after extubation. Group B received 200 mcg BIS 6 h and 24 h after extubation. Control group received the same scheduled treatment as Group A, but the BIS was replaced with 2 ml normal saline. The patients were evaluated for POST and hoarseness 1, 24 and 48h after extubation and the status of laryngopharynx was examined and recorded as well.
Results: The incidences of post-operation complaints in three groups were 72.5%, 82.5% and 87.55% for POST, and 37.3%, 52.5% and 75% for hoarseness, respectively. There was no statistically significant difference in the incidence of POST between three groups. However, hoarseness occurred significantly less frequently in Group A in comparison to Group B and control group (P<0.05). One hour post extubation, Group A exhibited significantly less severe POST and hoarseness compared to the other two groups (P<0.05), which disappeared 24 h later. One hour after extubation both VAS scores of POST and hoarseness were significantly lower in Group A than those in the other two groups (P<0.05). The mucositis scores of laryngopharynx at 1,24 and 48 h post extubation were significantly lower in Group A compared to the other two groups (P<0.05).
Conclusions: The prophylactic use of inhaled budesonide suspension significantly decreases the incidence and severity of sore throat and hoarseness after tracheal intubation.