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Prophylactic Strategy for Peritoneal Recurrence after Curative Operation in Pancreatic Cancer | OMICS International | Abstract
ISSN: 2157-7099

Journal of Cytology & Histology
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Review Article

Prophylactic Strategy for Peritoneal Recurrence after Curative Operation in Pancreatic Cancer

Kenichiro Yamamoto1*, Shinya Shimada1, Masafumi Kuramoto1, Satoshi Ikeshima1, Toshiro Masuda1, Kenichi Nakamura1, Shinichi Yoshimatsu2, Masayuki Urata2 and Hideo Baba3

1Department of Surgery, Kumamoto Social Insurance General Hospital, Yatsushiro, Kumamoto, Japan

2Department of Gastroenterology and Hepatology, Kumamoto Social Insurance General Hospital, Yatsushiro, Kumamoto, Japan

3Department of Gastroenterological Surgery, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan

*Corresponding Author:
Kenichiro Yamamoto
Department of Surgery
Kumamoto Social Insurance General Hospital
10-10 Tohricho, Yatsushiro
Kumamoto 866-8660, Japan
Tel: +81-965-32-7111
Fax: +81-965-32-2772
E-mail: [email protected]

Received date: August 08, 2013; Accepted date: September 25, 2013; Published date: September 27, 2013

Citation: Yamamoto K, Shimada S, Kuramoto M, Ikeshima S,Masuda T (2013) Prophylactic Strategy for Peritoneal Recurrence after Curative Operation in Pancreatic Cancer. J Cytol Histol 4:185. doi: 10.4172/2157-7099.1000185

Copyright: © 2013 Yamamoto K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Even though curative surgery has been performed for patients with pancreatic cancer without peritoneal free cancer cells at laparotomy, many patients die of peritoneal recurrence. The reason for this fact is postulated that the surgical procedure itself could cause spread of cancer cells into peritoneal cavity. To identify the free cancer cells spilled in the peritoneal cavity during the operation, we have established real-time quantitative reverse transcription Polymerase Chain Reaction (RT-PCR) system. Moreover, we have devised Extensive Intraoperative Peritoneal Lavage (EIPL) therapy as a very simple and non-aggressive prophylactic treatment for peritoneal dissemination of gastric cancer patients with peritoneal free cancer cells. In this paper, we review the validity of EIPL therapy navigated by real-time quantitative RT-PCR detecting free cancer cells in the peritoneal cavity during operation, and the effect of this therapy on the survival after curative operations in patients with pancreatic cancer


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