alexa Prospective Tuberculosis Treatment: Peptides, Immunity and Autophagy
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
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Review Article

Prospective Tuberculosis Treatment: Peptides, Immunity and Autophagy

Jonathan Gabriel Rodriguez Plaza1, Bruno Rivas-Santiago2, Rogelio Hernandez-Pando3 and Gabriel Del Rio1*

1Department of Biochemistry and structural biology, Instituto de Fisiologia Celuar, UNAM, Mexico DF 04510, Mexico

2Medical Research Unit-Zactecas, Mexican Institute for Social Security-IMSS, Mexico

3Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition “Salvador Zubirán”, Mexico

Corresponding Author:
Gabriel Del Rio
Universidad Nacional Autonoma de Mexico
Biochemistry and structural biology
Circuito exterior s/n, Delegacion Coyacan
Mexico DF, DF 04510, Mexico
Tel: (55) 5622 5663
Fax: (55) 5622 5663
E-mail: [email protected]

Received date: July 29, 2014; Accepted date: September 22, 2014; Published date: September 30, 2014

Citation: Rodriguez Plaza JG, Rivas-Santiago B, Hernandez-Pando, Rio GD (2014) Prospective Tuberculosis Treatment: Peptides, Immunity and Autophagy. J Mol Genet Med 8:128. doi:10.4172/1747-0862.1000128

Copyright: © 2014 Rodriguez Plaza JG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

 

Abstract

Tuberculosis (TB) is a world-leading infectious disease caused by Mycobacterium tuberculosis (Mtb). The current treatment lasts 6 months and has contributed to the development of multidrug resistant (MDR) strains that nowadays cause almost half a million deaths around the globe. Forty years of research have rendered only 1 new drug to treat the new MDR strains. In the current review we present emerging trends to treat TB particularly focused on natural and synthetic peptides. The ability of some of these peptides to display multifunctional roles in TB treatment, particularly immune system modulation through autophagy and direct antimicrobial activity against Mtb, may present advantages to control the impact of this disease. We review the mechanisms of action relevant in the development of multifunctional peptides that may lead to evaluate new ways to treat TB, a disease that has accompanied human society for centuries

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