Protection of the Ischemic Myocardium during the Reperfusion: Between Hope and Reality
Bopassa Jean Chrisostome*
Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA 90095-1778, USA
- *Corresponding Author:
- Dr. Jean Chrisostome Bopassa
David Geffen School of Medicine,
Department of Anesthesiology, UCLA
BH-520A CHS Box 957115
Los Angeles, CA 90095-7115
E-mail: [email protected]
Received date: February 07 , 2012; Accepted date: April 28, 2012; Published date: May 10, 2012
Citation: Chrisostome BJ (2012) Protection of the Ischemic Myocardium during the Reperfusion: Between Hope and Reality. J Develop Drugs 1:101 doi:10.4172/2329-6631.1000101
Copyright: © 2012 Chrisostome BJ. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The heart is an organ that requires an important energy input to ensure its contractile function. Myocardial ischemia happens when there is a deficiency of blood flow that is responsible for the passage from an aerobic to anaerobic metabolism. Myocardial ischemia results from an imbalance between inputs and the needs of nutrient and oxygen to the myocardium. The restoration of myocardial perfusion called reperfusion is a way to save the ischemic myocardium. However, although reperfusion is beneficial for the survival of the ischemic myocardium, it also induces a deleterious effect in addition to that of ischemic stress. Three decade ago, while several studies, strived to elucidate the protective effect of preconditioning, a phenomenon performed before ischemia and having a powerful protective effects against ischemia/reperfusion injury, very few have believed in the possibility of protecting the myocardium after ischemia (during reperfusion). Actually, both ischemic and pharmacological postconditioning as well as controlled reperfusion methods to protect the ischemic heart has proved effective in the reduction of damage related to ischemia/reperfusion. The possibility of protecting the myocardium during reperfusion opens a new area in the research against damage caused by ischemia/reperfusion because these methods are easily transferable in a clinic setting.