Protective Effect of a Synthetic Antioxidant "Acetyl Gallate Derivative" Against Dimethoate Induced DNA Damage and Oxidant/Antioxidant Status in Male Rats
Received Date: Jul 02, 2012 / Accepted Date: Sep 13, 2012 / Published Date: Sep 18, 2012
The present study was conducted to investigate the protective effects of a synthetic antioxidant “acetyl gallate derivative” (SAC) against hepatic oxidative stress and brain DNA damage induced by dimethoate (DM) in male rats. DM was orally administrated to the rats at a dose of 38.7 mg kg-1 b.wt. (1/10 LD50), for 28 consecutive days. Additional DM groups received either SAC or vitamin C (VC) at a dose of 200 mg kg-1 b.wt. 30 min before DM administration. Compared to the control, DM induced a statistical reduction in body weight gain, while induced a statistical increase in absolute and relative liver weights. Oral administration of DM significantly caused increases in hepatic lipid peroxidation (LPO) and activities of antioxidant enzymes including catalase (CAT), superoxide dismutase (SOD) and glutathione-s-transferease (GST), while caused decreases in glutathione content (GSH) and serum cholinesterase(ChE) activity. Administration of SAC attenuates LPO, GSH content and antioxidant enzymes system. The severity of brain DNA damage monitored by damage index (DI) and damage frequency % (DF) induced by DM was mitigated after administration of SAC. In conclusion, supplementation of SAC is more reliable than VC in attenuating relative liver weight, SOD, GST, and brain DNA damage.
Keywords: Antioxidant enzymes; Dimethoate; DNA damage; Acetyl gallate derivative; Oxidative stress
Citation: Heikal TM, Mossa ATH, Nawwar GAM, El-Sherbiny M, Ghanem HZ (2012) Protective Effect of a Synthetic Antioxidant “Acetyl Gallate Derivative” Against Dimethoate Induced DNA Damage and Oxidant/Antioxidant Status in Male Rats. J Environ Anal Toxicol 2: 155. Doi: 10.4172/2161-0525.1000155
Copyright: © 2012 Heikal TM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author and source are credited.
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