alexa Protective Effect of a Synthetic Antioxidant â€Â
ISSN: 2161-0525

Journal of Environmental & Analytical Toxicology
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Research Article

Protective Effect of a Synthetic Antioxidant “Acetyl Gallate Derivative” Against Dimethoate Induced DNA Damage and Oxidant/Antioxidant Status in Male Rats

Tarek M. Heikal1*, Abdel-Tawab H. Mossa1, Galal A. M. Nawwar2, Mahmoud El-Sherbiny3 and Hassan Z. Ghanem3
1Pesticide Chemistry Department, National Research Centre, Cairo, Egypt
2Green Chemistry Department, National Research Centre, Cairo, Egypt
3Therapeutic Chemistry Department, National Research Centre, Cairo, Egypt
Corresponding Author : Tarek M. Heikal
Environmental Toxicology Research Unit (ETRU)
Pesticide Chemistry Department, National Research Centre
Tahrir Street, P.O. Box 12311, Dokki, Cairo, Egypt
Tel: 202-33371211-33371615
Fax: 202-33370931
E-mail: [email protected]
Received July 02, 2012; Accepted September 13, 2012; Published September 18, 2012
Citation: Heikal TM, Mossa ATH, Nawwar GAM, El-Sherbiny M, Ghanem HZ (2012) Protective Effect of a Synthetic Antioxidant “Acetyl Gallate Derivative” Against Dimethoate Induced DNA Damage and Oxidant/Antioxidant Status in Male Rats. J Environ Anal Toxicol 2:155. doi: 10.4172/2161-0525.1000155
Copyright: © 2012 Heikal TM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

The present study was conducted to investigate the protective effects of a synthetic antioxidant “acetyl gallate derivative” (SAC) against hepatic oxidative stress and brain DNA damage induced by dimethoate (DM) in male rats. DM was orally administrated to the rats at a dose of 38.7 mg kg-1 b.wt. (1/10 LD50), for 28 consecutive days. Additional DM groups received either SAC or vitamin C (VC) at a dose of 200 mg kg-1 b.wt. 30 min before DM administration. Compared to the control, DM induced a statistical reduction in body weight gain, while induced a statistical increase in absolute and relative liver weights. Oral administration of DM significantly caused increases in hepatic lipid peroxidation (LPO) and activities of antioxidant enzymes including catalase (CAT), superoxide dismutase (SOD) and glutathione-s-transferease (GST), while caused decreases in glutathione content (GSH) and serum cholinesterase(ChE) activity. Administration of SAC attenuates LPO, GSH content and antioxidant enzymes system. The severity of brain DNA damage monitored by damage index (DI) and damage frequency % (DF) induced by DM was mitigated after administration of SAC. In conclusion, supplementation of SAC is more reliable than VC in attenuating relative liver weight, SOD, GST, and brain DNA damage.

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