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Protective Effect of Spirodela polyrhiza on Various Organs of Arsenicinduced Wistar Albino Rats | OMICS International | Abstract
ISSN: 2157-7099

Journal of Cytology & Histology
Open Access

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Research Article

Protective Effect of Spirodela polyrhiza on Various Organs of Arsenicinduced Wistar Albino Rats

Salma Chowdhury DU1, Islam S2, Akter R3, Islam F3, Mazumdar S3, Khaleda L1, Rahman Z2and Mohammad Al-Forkan1*


1Department of Genetic Engineering and Biotechnology, University of Chittagong, Bangladesh

2Department of Pathology, Chittagong Medical College; Chittagong, Bangladesh

3Bangladesh Council of Scientific & Industrial Research Laboratories, Chittagong, Bangladesh

Corresponding Author:
Mohammad Al-Forkan
Department of Genetic Engineering and Biotechnology
University of Chittagong, Chittagong-4331
Tel: +880-1819383213
Fax: +88-031-2606014
E-mail: [email protected]

Received March 30, 2016; Accepted April 18, 2016; Published April 28, 2016.

Citation: Salma Chowdhury DU, Islam S, Akter R, Islam F, Mazumdar S, et al. (2016) Protective Effect of Spirodela polyrhiza on Various Organs of Arsenicinduced Wistar Albino Rats. J Cytol Histol 7:410. doi:10.4172/2157-7099.1000410

Copyright: © 2016 Salma Chowdhury DU, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Our study was undertaken to assess the protective effect of Spirodela polyrhiza against sodium arseniteinduced toxicity in experimental model. Animals were divided into six groups. The first group was used as control group while the other groups were treated with S. polyrhiza, sodium arsenite (10 ppm), 10 ppm As plus S. polyrhiza, sodium arsenite (30 ppm), and 30 ppm As plus S. polyrhiza respectively. Organs (kidney, spleen and heart) were collected at the end of the experiment for conducting histopathological analysis and measuring the amount of deposited arsenic. Tubular epithelium necrosis was seen affecting less than 50% of all renal specimens, on the other hand slightly enlarged white pulp region in splenic tissue were found in the groups of Wistar rat where S. polyrhiza and arsenic was administered concomitantly. Moreover, the observed moderate tissue changes (edema and muscle necrosis) in cardiac specimens of arsenic treated groups were found to be mild in the S. polyrhiza +arsenic treated groups. It is noteworthy to mention that S. polyrhiza not only reversed the arsenic-induced toxicity but also reduced the tissue arsenic load in Wistar rats to a considerable extent. Overall, the results indicated that S. polyrhiza might become useful in mitigating the toxic effects of arsenic.