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Protective Effect of Vitamin C on Biochemical Alterations Induced by Subchronic Co-administration of Chlorpyrifos and Lead in Wistar Rats | OMICS International | Abstract
ISSN: 2161-0525

Journal of Environmental & Analytical Toxicology
Open Access

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Research Article

Protective Effect of Vitamin C on Biochemical Alterations Induced by Subchronic Co-administration of Chlorpyrifos and Lead in Wistar Rats

Ambali SF1*, Angani M1, Adole AO1, Kawu MU1, Shittu M1, Akande MG2 and Oladipo OO3
1Department of Veterinary Physiology and Pharmacology,Ahmadu Bello University, Zaria, Nigeria
2Department of Veterinary Pharmacology and Toxicology, University of Abuja, Nigeria
3National Veterinary Research Institute, Vom, Nigeria
Corresponding Author : Ambali SF
Department of Veterinary Physiology and Pharmacology
Ahmadu Bello University, Zaria, Nigeria
Tel: +234 8037015411
E-mail: [email protected]; [email protected]
Received October 26, 2011; Accepted November 25, 2011; Published November 28, 2011
Citation: Ambali SF, Angani M, Adole AO, Kawu MU, Shittu M, et al. (2011) Protective effect of vitamin C on biochemical alterations induced by subchronic co-administration of chlorpyrifos and lead in Wistar rats. J Environment Analytic Toxicol 1:108. doi: 10.4172/2161-0525.1000108
Copyright: © 2011 Ambali SF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Oxidative stress is one of the molecular mechanisms involved in chlorpyrifos (CPF) and lead poisoning. The present study investigated the role of vitamin C in mitigating the biochemical alterations induced by co-administration of CPF and lead. Forty adult male Wistar rats divided into 4 groups of 5 animals in each group were used for this study. Group I was dosed with corn oil (2 ml/kg) while group II was given vitamin C (100 mg/kg). Group III was co-administered CPF ( 4.25 mg/kg~ 1/20th LD50) and Pb (225 mg/kg~1/20th LD50) while group IV was pretreated with vitamin C (100 mg/kg) and then co-administered with CPF (4.25 mg/kg) and Pb (225 mg/kg), 30 min later. The regimens were administered once daily by oral gavage for a period of 9 weeks. The rats were sacrificed and sera obtained from the blood samples were analyzed for the total proteins, albumin, globulin, electrolytes (Na+, K+, Cl-), urea and liver malonaldehyde concentrations. The activities of serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma-glutamyl transferase and lactate dehydrogenase were evaluated. The result showed that alterations in the biochemical parameters induced by co-exposure to CPF and lead were mitigated by pretreatment with vitamin C.