alexa Protective Effects of Cyclohexyl methyl dithiocarbamates Sodium Salts on Diclofenac Induced Reproductive Toxicity in Male Albino Rats | OMICS International
ISSN: 2167-0501

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Research Article

Protective Effects of Cyclohexyl methyl dithiocarbamates Sodium Salts on Diclofenac Induced Reproductive Toxicity in Male Albino Rats

Adegbegi J Ademuyiwa1*, Jose R Adeolu1 and Adefegha S Adeniyi2
1Department of Science Laboratory Technology, Rufus Giwa Polytechnic, Owo, Ondo State, Nigeria
2Department of Biochemistry, Federal University of Technology, Akure, Ondo State, Nigeria
Corresponding Author : Adegbegi J Ademuyiwa
Department of Science Laboratory Technology
Rufus Giwa Polytechnic
Owo, Ondo State, Nigeria
Tel: +234 8066149905
E-mail: [email protected]
Received November 13, 2014; Accepted December 12, 2014; Published December 19, 2014
Citation: Adegbegi AJ, Jose AR, Adefegha AS (2014) Protective Effects of Cyclohexyl methyl dithiocarbamates Sodium Salts on Diclofenac Induced Reproductive Toxicity in Male Albino Rats. Biochem Pharmacol (Los Angel) 4:155. doi:10.4172/2167-0501.1000155
Copyright: © 2014 Ademuyiwa AJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The present study investigates the effect of cyclohexylmethyldithiocarbamates sodium salt (a synthetic compound) and vitamin E against diclofenac-induced blood and testes of experimental Wistar male albino rats. The study consists of six groups of six rats each. Group I (control) received corn oil (3 ml/kg b.w), Group II received diclofenac (100 mg/kg b.w), Group III rats were treated with diclofenac and cyclohexylmethyldithiocarbamates sodium salt (30 mg/kg b.w), Group IV was administered diclofenac and Vitamin E (30 mg/kg b.w), Group V was given cyclohexylmethyldithiocarbamates sodium salt (30 mg/kg b.w) only and Group VI received vitamin E only. The results showed a significant (p<0.05) decrease in the daily sperm production in the diclofenac only treated rats, diclofenac with Na (HxMedtc), diclofenac with vitamin E treated rats and Na (HxMedtc) treated rats but no significant (p>0.05) in the vitamin E only treated rats when compared with the control. There was a significant (p<0.05) decrease in the Testicular sperm number (TSN) in the diclofenac only treated rats, diclofenac with Vitamin E treated rats and vitamin E only treated rats and no significant (p>0.05) decrease in the diclofenac with Na (HxMedtc) treated rats and Na (HxMedtc) only treated rats when compared with the control. Also, there was a significant (p<0.05) decrease in TSN in the diclofenac with Na (HxMedtc) treated rats and diclofenac with vitamin E treated rats when compared with diclofenac only treated rats. And a decrease (p<0.05) in the daily sperm production (DSP) in the diclofenac only treated rats, and diclofenac with cyclohexylmethyldithiocarbamate sodium salt only treated rats when compared with the control.

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