alexa Protective Effects of Laminarin on Cisplatin-induced Ototoxicity in HEIOC1 Auditory Cells | OMICS International | Abstract
ISSN: 2155-9600

Journal of Nutrition & Food Sciences
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Protective Effects of Laminarin on Cisplatin-induced Ototoxicity in HEIOC1 Auditory Cells

Yuhang Han1,2, Suming Shi1,2, Lei Xu1,2, Yuechen Han1,2, Jianfeng Li1,2, Qian Sun3, Qingyin Zheng4, Xiaohui Bai1,2* and Haibo Wang1,2*

1Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, P.R. China

2Shandong Provincial Key Laboratory of Otology, Jinan 250022, P.R. China

3Human Genetics Department, Emory University, Atlanta, GA, USA

4Department of Otolaryngology-Head and Neck Surgery, Case Western Reserve University, Cleveland, OH, USA

*Corresponding Authors:
W ang H
Department of Otolaryngology-Head and Neck Surgery
Shandong Provincial Hospital Af filiated to Shandong University
Jinan 250021, P.R. China, Shandong Provincial Key Laboratory of Otology
Jinan 250022, P.R. China
Tel: 053187938911
E-mail: [email protected]
 
Bai X
Department of Otolaryngology-Head and Neck Surgery
Shandong Provincial Hospital Affiliated to Shandong University
Jinan 250021, P.R. China, Shandong Provincial Key Laboratory of Otology
Jinan 250022, P.R. China
Tel: 053187938911
E-mail: [email protected]

Received date: July 05, 2016; Accepted date: July 22, 2016; Published date: July 27, 2016

Citation: Han Y, Shi S, Xu L, Han Y, Li J, et al. (2016) Protective Effects of Laminarin on Cisplatin-induced Ototoxicity in HEI-OC1 Auditory Cells. J Nutr Food Sci 6:537. doi: 10.4172/2155-9600.1000537

Copyright: © 2016 Han Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Cisplatin is an effective chemotherapeutic agent against many common types of cancers. However, one of its most severe and debilitating side effects is ototoxicity. The purpose of this study was to investigate the mechanisms of laminarin protective effects on cisplatin-induced damage in HEI-OC1 auditory cell line. In our research, HEI-OC1 cells were pretreated with laminarin and then exposed to cisplatin. Here, we examined the cell viability, cell apoptosis and the factors associated with apoptotic pathway. Compared with cisplatin injured group, pretreatment with laminarin increased cell viability and decreased the cell apoptosis and necrosis. Furthermore, treatment with laminarin reduced intracellular ROS production, bax mRNA, and cleaved caspase-3, caspase-9, caspase-8 expression, but increased the bcl-2 mRNA level. The protection was ascribed to the radical scavenging activity of laminarin, and the inhibition of both mitochondrial apoptosis pathway and extrinsic apoptotic pathway.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7