alexa Protective Effects of Retinoic Acid on Streptozotocin-Induced Type I Diabetes
ISSN: 2165-7092

Pancreatic Disorders & Therapy
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Review Article

Protective Effects of Retinoic Acid on Streptozotocin-Induced Type I Diabetes

Eduardo Molina-Jijón, Rafael Rodríguez-Muñoz, and José L. Reyes*
Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies of the National Polytechnic Institute (Cinvestav-IPN), México D. F., 07360, Mexico
Corresponding Author : José L. Reyes
MD, PhD. Department of Physiology, Biophysics and Neurosciences
Center for Research and Advanced Studies, National Polytechnic Institute (Cinvestav-IPN)
Mexico D. F., 07360, Mexico
Tel: +55 5747 3962/3800/5147/5723
Fax: + 55 5747 3754
E-mail:[email protected]
Received Aprial 04 2014; Accepted July 26 2014; Published July 28 2014
Citation: Jijon EM, Munoz RR, Reyes JL (2014) Protective effects of Retinoic acid on Streptozotocin-induced Type I Diabetes. Pancreat Disord Ther 4:141. doi:10.4172/2165-7092.1000141
Copyright: © 2014 Molina-Jijón, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

All-trans-Retinoic Acid (atRA) is a biologically active derivative of vitamin A that regulates numerous physiological processes through its interaction with nuclear retinoid receptor proteins, termed as Retinoid Acid Receptors (RARs) and Retinoid X Receptors (RXR). Retinoid signaling is diverse and its role in embryonic development, adult growth and development, maintenance of immunity and epithelial barriers, and vision has been elucidated. An increased body of evidence suggests that altered metabolism of retinoic acid under experimental type-1 diabetes conditions induced with streptozotocin (STZ) is related to insulin deficiency. In several experimental approaches the role of treatment in STZ-induced diabetes has been tested. This review summarizes current knowledge on the role of retinoids and atRA in the improvement of pathological alterations in STZ-induced experimental type-1 diabetes in kidney, retina, skin and nervous system.

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