Protective Effects of Selenium and Alpha-Tocopherol against Lead-Induced Hepatic and Renal Toxicity in Oreochromis Niloticus
- *Corresponding Author:
- Shimaa AE
Department of Clinical Pathology
Faculty of Veterinary Medicine
Zagazig University, Zagazig, Egypt
E-mail: [email protected]
Received Date: November 17, 2014; Accepted Date: December 10, 2014; Published Date: January 12, 2015
Citation: Elgaml SA, Khalil R, Hashish EA, El-Murr A (2015) Protective Effects of Selenium and Alpha-Tocopherol against Lead-Induced Hepatic and Renal Toxicity in Oreochromis Niloticus. J Aquac Res Development 6:299. doi: 10.4172/2155-9546.1000299
Copyright: © 2015 Elgaml SA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Lead is a serious poison causing serious injury or death. Current study was designed to investigate the potential protective effect of selenium (Se) and alpha-tocopherol (alpha-toc) against the hepatic and renal toxicity of lead acetate in Oreochromis niloticus. Two hundred and twenty five O. niloticus were divided into five groups; control, lead acetate treated (73.40 mg/liter), Se treated (4 mg sodium selenite/ kg diet), alpha-toc treated (200 mg/kg diet) plus Se + alpha-toc co-treated groups for 10 weeks. Levels of aspartate aminotransferase (AST), alanine transaminase (ALT), total protein, urea, creatinine, calcium (Ca), inorganic phosphate (P), magnesium (Mg), superoxide dismutase (SOD), reduced glutathione (GSH) and the lipid peroxidation index (MDA) were determined The results revealed an increase in the levels of liver enzymes, urea, creatinine and MDA; meanwhile, the total protein, Ca, P, Mg, SOD and GSH were decreased. Therefore, it could be concluded that selenium (Se) and alpha-tocopherol (alpha-toc) may be useful tool to minimize the toxic effects of lead toxicity by its potent antioxidant activity.