alexa Protective Effects of Wheat Sprout on Testicular Toxicity in Male Rats Exposed to Lead | OMICS International | Abstract
ISSN: 2161-038X

Reproductive System & Sexual Disorders: Current Research
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Research Article

Protective Effects of Wheat Sprout on Testicular Toxicity in Male Rats Exposed to Lead

Masoud Adibmoradi1, Hassan Morovvati1*, Hamid Reza Moradi1, Mohammad-Taghi Sheybani1, Jamileh Salar Amoli1, Ramin Mazaheri Nezhad Fard2 and Ali Kalantari Hesari1

1Division of Histology Department of Basic Science, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

2Division of Food Microbiology, Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

*Corresponding Author:
Morovvati H
Faculty of Veterinary Medicine
University of Tehran
Tehran, Iran
Fax: +98.021.66933222
Email: [email protected]

Received date: September 26, 2015; Accepted date: November 07, 2015; Published date: November 13, 2015

Citation: Adibmoradi M, Morovvati H, Moradi HR, Sheybani MT, Amoli JS, et al. (2015) Protective Effects of Wheat Sprout on Testicular Toxicity in Male Rats Exposed to Lead. Reprod Syst Sex Disord 4:156. doi:10.4172/2161-038X.1000156

Copyright: © 2015 Adibmoradi M, et al., This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Objective: Negative effects of lead on the male reproductive system and sperm fertility parameters have been shown broadly. In recent years, use of medicinal herbs in reducing heavy metal toxicities has increased worldwide. One of these herbals, wheat sprout, contains high amount of vitamins (especially vitamin E), antioxidants and phytoestrogen compounds. This study investigated the effects of wheat sprout extract (WSE) and vitamin E on testicular oxidative stress in rats exposed to lead acetate.

Methods: Thirty-five rats were divided randomly into seven groups: G1 (control group) received 1 ml/kg/day of normal saline, G2 received 20 mg/kg/day of lead acetate, G3 and G4 received 100 mg/kg/day and 200 mg/kg/day of WSE respectively, G5 and G6 received 100 mg/kg/day and 200 mg/kg/day of WSE respectively with 20 mg/kg/day of lead acetate, and G7 received 100 mg/kg/day of vitamin E with 20 mg/kg/day of lead acetate. After 35 days, rats were sacrificed and blood, sperm, liver and testicle tissue samples were collected for histomorphological and histochemical studies.

Results: Results showed that count, motility and viability of sperms decreased following the administration of lead acetate (P<0.01). Histomorphological studies showed a significant decrease in tubular differentiation index (TDI), spermiogenesis index (SI), repopulation index (RI), number of Leydig and Sertoli cells, and epithelium height and diameter of seminiferous tubules in groups receiving lead acetate (P<0.05).

Conclusion: Summary, results of the current study show that dose dependent WSE significantly prevents testicular toxicity and oxidative stress effects of lead acetate.


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