Protein Interactions in the Last Steps of the Endosomal Degradative Pathway
Celina Amaya* and María Isabel Colombo
Laboratory of Cellular and Molecular Biology, Institute of Histology and Embryology (IHEM) - National University of Cuyo-CONICET, Faculty of Medical Sciences, Mendoza, Argentina
- *Corresponding Author:
- Celina Amaya
Laboratory of Cellular and Molecular Biology
Institute of Histology and Embryology (IHEM) - National University of Cuyo- CONICET
Faculty of Medical Sciences, Mendoza, Argentina
Tel: 54 -261- 4494143
E-mail: [email protected]
Received date: May 09, 2017; Accepted date: June 19, 2017; Published date: June 27, 2017
Citation: Amaya C, Isabel Colombo M (2017) Protein Interactions in the Last Steps of the Endosomal Degradative Pathway. J Cell Signal 2:153.
Copyright: © 2017 Amaya C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Endocytosis, the procedure whereby the plasma membrane invaginates to form endosomes, is essential for bringing many materials into the cell and for membrane recycling. Multiple cellular processes require endocytosis, including nutrient uptake, signal transduction, and cell-pathogen interactions. The fate of cargoes internalized in early endosomes depends on their nature. Some cargoes are recycled back to the plasma membrane, while others are delivered to late endosomes and finally degraded after fusion with lysosomes. During these processes, endosomes suffer translocation from the cell periphery to the perinuclear region, which is accompanied by fusion, invagination, tubulation, and membrane fission events. As expected, complex cellular signaling processes tightly control the endocytic pathway at different steps. Several GTPases, such as Rab7, Rab24 and Arl8b, associated with their effectors RILP, FYCO1 and PLEKHM1, are crucial for endosome trafficking. Here, we examine the current knowledge concerning endosome-lysosome fusion, emphasizing the main protein interactions related to this process.