alexa Proteolytically-cleaved Fragments of Cell-surface Proteins from Live Tumor Cells Stimulate Anti-tumor Immune Response In vitro
ISSN: 2157-2518

Journal of Carcinogenesis & Mutagenesis
Open Access

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Research Article

Proteolytically-cleaved Fragments of Cell-surface Proteins from Live Tumor Cells Stimulate Anti-tumor Immune Response In vitro

Elena E Balashova1,3 and Petr G. Lokhov2,3*

1Cardiology Research Center, 3rd Cherepkovskaya Street 15A, 121552, Moscow, Russia

2Institute of Biomedical Chemistry RAMS, 119121, Pogodinskaya st., 10, Moscow, Russia

3ZAO BioBohemia, Moscow, Russia

*Corresponding Author:
Petr G. Lokhov
Cardiology Research Center
3rd Cherepkovskaya Street 15A
121552, Moscow, Russia
Tel: +7 903 744 51 91
Fax: +7 495 143 22 77
E-mail: [email protected]

Received date: June 15, 2010; Accepted date: September 01, 2010; Published date: September 01, 2010

Citation: Balashova EE, Lokhov PG (2010) Proteolytically-cleaved Fragments of Cell-surface Proteins from Live Tumor Cells Stimulate Anti-tumor Immune Response In vitro. J Carcinogene Mutagene 1:103. doi: 10.4172/2157-2518.1000103

Copyright: © 2010 Balashova EE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Antigens expressed on the surface of cancer cells are accessible targets for both humoral and cell-mediated immune responses, and are therefore potential candidates for vaccine development. Treating surface of live human breast adenocarcinoma cells (MCF-7) with trypsin yields a digest that contains 0.7% of total cell protein. Despite this difference, the trypsin digest stimulates in cytotoxicity assays anti-tumor response which kills 10-40% more cancer cells than those stimulated with cells themselves. From these results, we concluded that trypsin digest obtained from live cancer cells contains the essential antigens to induce an immune-mediated anti-tumor effect, and therefore, is candidate for anti-tumor vaccine development.

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