alexa Proteomic Analyses of Proteins Differentially Expressed in Recurrent and Primary Pterygia
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
Open Access

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Research Article

Proteomic Analyses of Proteins Differentially Expressed in Recurrent and Primary Pterygia

Takashi Kanamoto1*, Nazariy Souchelnytskyi2, Ryotaro Toda1, Ulfah Rimayanti1 and Yoshiaki Kiuch1

1Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Hiroshima University

2Karolinska Biomics Centre, Department of Oncology Pathology, Karolinska Institute, Stockholm, Sweden

*Corresponding Author:
Dr. Takashi Kanamoto
Department of Ophthalmology and Visual Sciences
Graduate School of Biomedical Sciences
Hiroshima University, 1-2-3, Kasumi, Minami-ku
Hiroshima, Japan-734-8551
Tel: +81-82-257-5247
Fax: +81-82-257-5249
E-mail: [email protected]

Received Date: March 06, 2011; Accepted Date: March 24, 2011; Published Date: March 26, 2011

Citation: Kanamoto T, Souchelnytskyi N, Toda R, Rimayanti U, Kiuch Y (2011) Proteomic Analyses of Proteins Differentially Expressed in Recurrent and Primary Pterygia. J Proteomics Bioinform 4:058-061. doi: 10.4172/jpb.1000167

Copyright: © 2011 Kanamoto T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



We describe a proteomic approach to identify proteins which may be involved in the recurrence of pterygia. Tissues from a recurrent pterygium and from a primary pterygium were surgically resected and were analyzed by proteomics to identify proteins that were significantly up- or down-regulated. The proteins showing significant differences in the two tissues were identified by mass spectrometry. Eleven proteins were differentially expressed; seven proteins were up-regulated and four proteins were down-regulated in the recurrent pterygium. The identified proteins are known to regulate cell cycle, cell organization, extracellular matrix, cholesterol metabolism, and cell signaling. Up- and down-regulation of proteins for cellular signaling are most likely involved in the recurrence of pterygia.


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