Proteomic Analyses of Proteins Differentially Expressed in Recurrent and Primary Pterygia
- *Corresponding Author:
- Dr. Takashi Kanamoto
Department of Ophthalmology and Visual Sciences
Graduate School of Biomedical Sciences
Hiroshima University, 1-2-3, Kasumi, Minami-ku
E-mail: [email protected]
Received Date: March 06, 2011; Accepted Date: March 24, 2011; Published Date: March 26, 2011
Citation: Kanamoto T, Souchelnytskyi N, Toda R, Rimayanti U, Kiuch Y (2011) Proteomic Analyses of Proteins Differentially Expressed in Recurrent and Primary Pterygia. J Proteomics Bioinform 4:058-061. doi: 10.4172/jpb.1000167
Copyright: © 2011 Kanamoto T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
We describe a proteomic approach to identify proteins which may be involved in the recurrence of pterygia. Tissues from a recurrent pterygium and from a primary pterygium were surgically resected and were analyzed by proteomics to identify proteins that were significantly up- or down-regulated. The proteins showing significant differences in the two tissues were identified by mass spectrometry. Eleven proteins were differentially expressed; seven proteins were up-regulated and four proteins were down-regulated in the recurrent pterygium. The identified proteins are known to regulate cell cycle, cell organization, extracellular matrix, cholesterol metabolism, and cell signaling. Up- and down-regulation of proteins for cellular signaling are most likely involved in the recurrence of pterygia.