alexa Proteomic Analysis of Rat Prefrontal Cortex after Chronic Lithium Treatment
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
Open Access

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Research Article

Proteomic Analysis of Rat Prefrontal Cortex after Chronic Lithium Treatment

Jaganathan Lakshmanan1,2,3, Ratnam S Seelan1,2,4, Muthusamy Thangavel1,2, Robert E Vadnal5, Anthony J Janckila6, Manuel F Casanova2, Latha K Parthasarathy1,2and Ranga N Parthasarathy1,2,7*

1Molecular Neuroscience and Bioinformatics Laboratories, Mental Health, Behavioral Science and Research Services, Robley Rex Veterans Affairs Medical Center, USA

2Department of Psychiatry and Behavioral Sciences, University of Louisville, USA

3Price Institute of Surgical Research, Department of Surgery, School of Medicine, University of Louisville, USA

4Department of Molecular, Cellular & Craniofacial Biology, School of Dentistry, University of Louisville, USA

5Eastern Colorado Health Care System, Department of Veterans Affairs, USA

6Special Hematology Lab, Robley Rex Veterans Affairs Medical Center and Department of Microbiology and Immunology, School of Medicine, University of Louisville, USA

7Department of Biochemistry and Molecular Biology, University of Louisville, USA

*Corresponding Author:
Dr. R. N. Parthasarathy
Molecular Neuroscience and Bioinformatics Laboratories
Robley Rex Veterans Affairs Medical Center
800 Zorn Avenue (151), Louisville, KY 40206, USA
Tel: 001-502-821-8600
Fax: 001- 502-287-6191

Received Date: May 20, 2012; Accepted Date: June 26, 2012; Published Date: June 30, 2012

Citation: Lakshmanan J, Seelan RS, Thangavel M, Vadnal RE, Janckila AJ, et al. (2012) Proteomic Analysis of Rat Prefrontal Cortex after Chronic Lithium Treatment. J Proteomics Bioinform 5: 140-146. doi: 10.4172/jpb.1000226

Copyright: © 2012 Lakshmanan J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Although lithium is widely used to treat Bipolar disorder (BD), its therapeutic role in BD is unclear. To gain insights into its mechanism of action we have used proteomic analysis to identify differentially expressed proteins in rat Prefrontal cortex (PFC), a region specifically affected in BD, after six weeks of lithium treatment. Proteins from control and lithium treated rat PFCs were separated by 2 Dimensional - Differential In-Gel Electrophoresis (2D-DIGE) and identified by mass spectrometry. Of the 2198 protein spots resolved, the abundance of 19 proteins was found to be significantly altered in the lithium treated group (with the levels of 5 proteins increasing and those of 14 decreasing). The levels of two protein spots exhibiting significant alteration after chronic lithium exposure were verified by Western blot analysis of rat PFC extracts. The 19 identified proteins represent novel targets for lithium action and participate in diverse functions that converge on a biological network that is specifically related to brain cell survival, prevention of neurodegeneration, and/or suppression of hyperactivity related signaling pathways. The identification of these targets should facilitate a better understanding of lithium’s overall effect on mood control.


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