alexa Proteomic Comparison of the Secreted Factors of Mesenchymal Stem Cells from Bone Marrow, Adipose Tissue and Dental Pulp | OMICS International | Abstract
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
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Research Article

Proteomic Comparison of the Secreted Factors of Mesenchymal Stem Cells from Bone Marrow, Adipose Tissue and Dental Pulp

Yuki Tachida1, Hidetaka Sakurai2, Junichi Okutsu2, Koji Suda1, Ryusuke Sugita1, Yumiko Yaginuma1, Yuji Ogura2, Kohei Shimada1, Fujio Isono1, Kazuishi Kubota2* and Hideki Kobayashi1*

1Frontier Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan

2Discovery Science and Technology Department, Daiichi Sankyo RD Novare Co., Ltd., Tokyo, Japan

These authors contributed equally to this work.

*Corresponding Authors:
Hideki Kobayashi
Frontier Research Laboratories
Daiichi Sankyo Co., Ltd. 1-2-58, Hiromatchi
Shinagawa-ku, Tokyo 140-8710, Japan
Tel: +81-3-3492-3131
Fax: +81-3-5740-3644
E-mail: [email protected]

Kazuishi Kubota
Discovery Science and Technology Department
Daiichi Sankyo RD Novare Co., Ltd. 1-16-13
Kitakasai, Edogawa-ku, Tokyo 134-8630, Japan
Tel: +81-3-5696-8267
Fax: +81-3-5696-3548
E-mail: [email protected]

Received date: November 05, 2015; Accepted date: December 07, 2015; Published date: December 07, 2015

Citation: Tachida Y, Sakurai H, Okutsu J, Suda K, Sugita R, Yaginuma Y, et al. (2015) Proteomic Comparison of the Secreted Factors of Mesenchymal Stem Cells from Bone Marrow, Adipose Tissue and Dental Pulp. J Proteomics Bioinform 8: 266-273. doi: 10.4172/jpb.1000379

Copyright: © 2015 Tachida Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Mesenchymal stem cells (MSCs) have therapeutic potential in various diseases, including myocardial infarction. Recently, the importance of the therapeutic effects of secreted factors from MSCs is increasing, but their identification has not progressed. In this study, we uncover the secreted protein profiles of MSCs derived from bone marrow, adipose tissue and dental pulp. Shotgun proteome analysis of conditioned MSC media by mass spectrometry identified 1533 proteins totally and 124 secreted proteins commonly produced among all three MSCs. The commonly secreted factors include already well-known factors whose functions are linked to MSCs’ biological effects, such as CTGF, SERPINE1, TGFB1, DKK3 and MYDGF, and also include newly identified factors whose roles are not well investigated, for example AIMP1, CLEC11A, GAS6, HDGF, INHBA, and PCSK5. Computational biological pathway analysis revealed that these common factors strongly relate to tissue regeneration pathways such as angiogenesis, migration, and inflammatory response. Further analysis showed enrichment of ossification, sprouting, and organ survival factors, suggesting connection to the functions closely related to MSCs’ therapeutic effects. This list of commonly secreted proteins could provide a reliable resource of biological factors which explain various effects of MSCs and would be useful for identifying new therapeutic factors produced from MSCs


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