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Proteomic Technologies to Develop Biomarkers and Functional Analyses for Bone and Soft Tissue Tumors | OMICS International | Abstract
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
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Review Article

Proteomic Technologies to Develop Biomarkers and Functional Analyses for Bone and Soft Tissue Tumors

Yoshiyuki Suehara1,2*, Shinji Kohsaka2, Daisuke Kubota1, Kenta Mukaihara1,3, Keisuke Akaike1,4, Reiko Mineki5, Tsutomu Fujimura5, Kazuo Kaneko1, Marc Ladanyi2, Tsuyoshi Saito4 and Tadashi Kondo3

1Department of Orthopedic Surgery, Juntendo University School of Medicine, Tokyo, Japan

2Department of Pathology, Memorial Sloan Ketteing Cancer Center, NY, USA

3Division of Pharmacoproteomics, National Cancer Center Research Institute, Tokyo, Japan

4Department of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan

5Laboratory of Biochemical Analysis, Central Laboratory of Medical Sciences, Juntendo University School of Medicine, Tokyo, Japan

*Corresponding Author:
Yoshiyuki Suehara
Department of Orthopedic Surgery
Juntendo University School of Medicine Hongo 2-1-1
Bunkyo-ku, Tokyo 113-8421, Japan
Tel: +81-3-3813-3111
Fax: +81-3-3813-3428
E-mail: [email protected]

Received date: September 10, 2013; Accepted date: October 22, 2013; Published date: October 25, 2013

Citation: Suehara Y, Kohsaka S, Kubota D, Mukaihara K, Akaike K, et al. (2013) Proteomic Technologies to Develop Biomarkers and Functional Analyses for Bone and Soft Tissue Tumors. J Proteomics Bioinform S3:001. doi: 10.4172/jpb.S3-001

Copyright: © 2013 Suehara Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Proteomics suggests that global protein expression studies can provide important clues for developing biomarkers and understanding tumor biology that cannot be obtained using other approaches. Proteomic studies, such as gelbased analyses and mass spectrometry-based analyses, have provided protein expression profiles that can be used to develop novel diagnostic and therapeutic biomarkers, allowing for the molecular classification of tumors. Recently, we used proteomic approaches to develop biomarkers for bone and soft tissue tumors and identified novel biomarkers for predicting the prognosis and chemosensitivity of bone and soft tissue tumors. Although the predictive power of these biomarkers has been confirmed in large validation studies, functional analyses of the biomarkers (proteins) remain to be conducted. In this article, we describe our proteomics methodology for identifying biomarkers and our approach to evaluating the functions of the biomarkers (proteins) and provide a few examples of our recent proteomic studies.


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