alexa Proteomics Analysis of Brain Meningiomas in Pursuit of
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
Open Access

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Research Article

Proteomics Analysis of Brain Meningiomas in Pursuit of Novel Biomarkers of the Aggressive Behavior

Garni Barkhoudarian1, Julian P Whitelegge2, Daniel F Kelly1 and Margaret Simonian2*#

1John Wayne Cancer Institute, Providence St John’s Health Center, USA

2David Geffen School of Medicine, University of California, Los Angeles (UCLA), USA

#Author prepared Manuscript

*Corresponding Author:
Margaret Simonian
David Geffen School of Medicine
Department of Biological Chemistry
University of California
Los Angeles (UCLA)
611 Charles E. Young Drive East
CA, 90095, USA
Tel: +1-310-794-7308
E-mail: [email protected]

Received Date: January 25, 2016; Accepted Date: February 24, 2016; Published Date: February 28, 2016

Citation: Barkhoudarian G, Whitelegge JP, Kelly DF, Simonian M (2016) Proteomics Analysis of Brain Meningiomas in Pursuit of Novel Biomarkers of the Aggressive Behavior. J Proteomics Bioinform 9:053-057. doi:10.4172/jpb.1000389

Copyright: © 2016 Barkhoudarian G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The aim of this pilot study was to evaluate the use of advanced proteomics techniques to identify novel protein markers that contribute to the transformation of benign meningiomas to more aggressive and malignant subtypes. Multiplex peptide stable isotope dimethyl labelling and nano LC-MS was used to identify and quantify the differentially expressed proteins in WHO Grade I, II and III meningioma tissues. The proteins identified will help elucidate the process of transformation to malignancy and may contribute to improved diagnosis and treatment of these aggressive tumors.

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