alexa Proteomics and Human Diseases
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
Open Access

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Review Article

Proteomics and Human Diseases

Rosa Lippolis1* and Maria De Angelis2

1Institute of Biomembranes and Bioenergetics, Italian National Research Council, (CNR) Bari, Italy

2Department of Soil, Plant and Food Sciences, University “A Moro”, Bari, Italy

*Corresponding Author:
Rosa Lippolis
Institute of Biomembranes and Bioenergetics (IBBE)
National Research Council (CNR)
70124 Bari – Italy
Tel: +39 080 5448509-31
Fax: +39 080 5448538
E-mail: [email protected]

Received Date: January 14, 2016; Accepted Date: March 03, 2016; Published Date: March 10, 2016

Citation: Lippolis R, De Angelis M (2016) Proteomics and Human Diseases. J Proteomics Bioinform 9:063-074. doi:10.4172/jpb.1000391

Copyright: © 2016 Lippolis R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Proteomics, the large scale study of proteins and protein variations, contributes to a better understanding of the molecular basis of variability in susceptibility to diseases that are associated with genetic diversity and environmental factors. The development of proteomic technologies has permitted the unprecedented large-scale identification of proteins in any biological system. Human proteomics point out physiological conditions that could greatly impact on medicine. This knowledge has the potential to decode the pathogenic mechanisms underlying diseases, elucidate potential risk factors and molecular targets for drug development and therapeutic interventions and identify promising biomolecules that could be developed for diagnostic and prognostic purposes and for improved disease management strategies. Thus proteomics can translate basic scientific discoveries into the clinical practice for precision medicine. This report provides an overview of targeted proteomics in biomedical clinical science by focusing on current stateof- the-art relatively to advances in biomedical proteomic applications. Future prospective metaproteomics and proteogenomics studies are highlighted.

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