Pruritus of Healing Wounds: why Scabs ItchHerbert B Allen*, Brittany Heffner, Trisha Dasgupta, Carrie Ann Cusack, Bhaswati Sen and Suresh G Joshi
Department of Dermatology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
- *Corresponding Author:
- Herbert B. Allen
Department of Dermatology
Drexel University College of Medicine
219 N. Broad St., 4th floor
Philadelphia, PA 19107, Pennsylvania, USA
E-mail: [email protected]
Received date: January 29, 2016; Accepted date: March 03, 2016; Published date: March 07, 2016
Citation: Allen HB, Heffner B, Dasgupta T, Cusack CA, Sen B, et al. (2016) Pruritus of Healing Wounds: why “Scabs” Itch. J Clin Exp Dermatol Res 7:333. doi: 10.4172/2155-9554.1000333
Copyright: © 2016 Allen HB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
We demonstrate herein the novel finding of occluded sweat ducts in healing wounds. We also show these occlusions are from biofilms because they are periodic acid Schiff positive which indicates they are polysaccharides and Congo red positive which shows they contain amyloid, which forms the infrastructure of biofilms. Further, from the skin immediately adjacent to the wounds, we have cultured staphylococci, all of which have the capability of forming biofilms as indicated by a colorimetric assay. These findings are similar to the findings in eczema, and we believe trigger the same response of the innate immune system in healing wounds, just as in eczema. The activated immune system (Toll-like receptor 2) then initiates the pathway leading to pruritus.