alexa P-Selectin is a Key Molecule Underlying the Pathophysio

Immunological Disorders & Immunotherapy
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Short Communication

P-Selectin is a Key Molecule Underlying the Pathophysiology of Aspirin- Exacerbated Respiratory Disease

Chihiro Mitsui1,3, Keiichi Kajiwara1, Hiroaki Hayashi1, Jun Ito1, Haruhisa Mita1, Emiko Ono1, Noritaka Higashi1,2, Yuma Fukutomi1, Kiyoshi Sekiya1, Takahiro Tsuburai1, Kazuo Akiyama1, Kazuhiko Yamamoto3 and Masami Taniguchi*1

1Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Kanagawa, Japan

2Japanese Red Cross Kumamoto Health Care Center, Kumamoto, Japan

3Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

*Corresponding Author:
Masami Taniguchi
Clinical Research Center for Allergy and Rheumatology
National Hospital Organization, Sagamihara National Hospital
Kanagawa, Japan
Tel: +81 (42) 742-8311
FAX: +81 (42) 742-7990
E-mail: [email protected]

Rec date: March 1, 2016, Acc date: March 31, 2016, Pub date: April 4, 2016

Citation: Mitsui C, Kajiwara K, Hayashi H, Ito J, Mita H, et al. (2016) P-Selectin is a Key Molecule Underlying the Pathophysiology of Aspirin- Exacerbated Respiratory Disease. Immunol Disord Immunother 1:104.

Copyright: ©2016 Mitsui C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Recently, the evidence for platelet association with allergic diseases has been established by many researches. Activated platelets contribute to airway hyper reactivity, bronchoconstriction, airway inflammation and airway remodeling in asthmatic patients. We aimed to clarify platelet activation and key molecules on platelets, which are mainly associated with the mechanism underlying aspirin-exacerbated respiratory disease.


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