alexa Psoriasis: A Sequela of Streptococcal Infection Similar
ISSN: 2327-5073

Clinical Microbiology: Open Access
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Psoriasis: A Sequela of Streptococcal Infection Similar to Acute Rheumatic Fever

Herbert B Allen*, Brett Miller, John Durkin and Suresh G Joshi

Drexel University College of Medicine Philadelphia, USA

*Corresponding Author:
Herbert B Allen
219 N. Broad St., 4th floor
Philadelphia, 19107, USA
Tel: 215-752-5550
Fax: 215-762-5570
E-mail: [email protected]

Received date: March 29, 2016; Accepted date: April 15, 2016; Published date: April 22, 2016

Citation: Allen HB, Miller B, Durkin J, Joshi SG (2016) Psoriasis: A Sequela of Streptococcal Infection Similar to Acute Rheumatic Fever. Clin Microbiol 5:244. doi:10.4172/2327-5073.1000244

Copyright: © 2016 Allen HB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



We propose that psoriasis is a sequela of streptococcal infection similar to acute rheumatic fever (ARF). This hypothesis arises from many different lines of evidence: a markedly elevated serum anti-streptococcal antibody is present in plaque psoriasis. However, cultures are routinely negative in psoriasis because the Group A Streptococcus pyogenes “hides” inside cells and inside biofilms and is thereby unculturable. The activation of either arm of the immune system is likely related to whether internalization or biofilm formation is predominant. With internalization, we postulate it is the adaptive immune system and with biofilm formation, the innate system. Lastly, prolonged treatment with anti-GAS antibiotics is effective in psoriasis as in ARF.


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