alexa Psychostimulants, Brain Membrane Lipids and Dopamine Transmission
ISSN: 2167-7956

Journal of Biomolecular Research & Therapeutics
Open Access

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Psychostimulants, Brain Membrane Lipids and Dopamine Transmission

Deborah J Luessen1 and Rong Chen1,2*

1Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA

2Center for the Neurobiology of Addiction Treatment, Winston Salem, NC 27157, USA

*Corresponding Author:
Rong Chen
Department of Physiologya and Pharmacology
Wake Forest School of Medicine
Winston Salem, NC 27157, USA
Tel: 336-716-8605
Fax: 336-716-8501
E-mail: [email protected]

Received date: May 09, 2016; Accepted date: May 28, 2016; Published date: June 06, 2016

Citation: Luessen DJ, Chen R (2016) Psychostimulants, Brain Membrane Lipids and Dopamine Transmission. J Biomol Res Ther 5:143. doi:10.4172/2167-7956.1000143

Copyright: © 2016 Luessen DJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Abstract

Membrane lipids in the brain play important roles in regulation of the membrane compartmentalization, function and signaling of neurotransmitter transporters and receptors. This review summarizes findings on changes in the composition and metabolism of brain membrane lipids such as phospholipids, cholesterol and sphingolipids following chronic exposure to psychostimulants. We also discussed the mechanisms by which membrane lipids regulate the membrane compartmentalization and function of dopamine transports and receptors in animal brain tissues and cultured cell lines. This review indicates that chronic psychostimulant exposure causes the remodeling of brain membrane lipid, which may contribute to psychostimulant-induced functional alterations in dopamine transporters and receptors. Brain membrane lipids could be exploited as a new avenue for pharmacological interventions of abnormal brain dopamine transmission and dopamine-related addiction behavior.

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