Type 1 IFN-alpha Receptor Expression in Peripheral Blood Lymphocytes Independently Predicts Sustained Virological Response in Chronic Hepatitis C Genotype 1b with High Viral Load
Kaori Kanayama, Koji Ishii*, Mie Shinohara, Michio Kogame, and Yasukiyo Sumino
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Toho University School of Medicine, Toho University, 6-11-1, Omorinishi, Otaku, Tokyo 143-8541, Japan
- *Corresponding Author:
- Koji Ishii
Division of Gastroenterology and Hepatology
Department of Internal Medicine
Toho University School of Medicine
Toho University, 6-11-1 Omorinishi, Ota-ku,
Tokyo 143-8541, Japan
E-mail: [email protected]
Received Date: September 28, 2012; Accepted Date: October 30, 2012; Published Date: November 01, 2012
Citation: Koji I, Kaori K, Mie S, Michio K, Masao S, et al. (2012) Type 1 IFN-alpha Receptor Expression in Peripheral Blood Lymphocytes Independently Predicts Sustained Virological Response in Chronic Hepatitis C Genotype 1b with High Viral Load. J Blood Lymph 2:109. doi:10.4172/2165-7831.1000109
Copyright: © 2012 Koji I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: We have been investigating serial changes in Type I Interferon (IFN) receptor alpha-2 (IFNAR-2) expression in peripheral blood leukocyte subsets in Chronic Hepatitis C (CHC) patients during IFN-based therapy. The aim of this study was to clarify whether changes in IFNAR-2 expression by peripheral blood leukocyte subsets are predictive factors for Sustained Virological Response (SVR).