Pulmonary Function in HIV-1 Vertically Infected Children
- *Corresponding Author:
- Fabrice Monpoux
Hopital de l’Archet
151 route de Saint Antoine de
Ginestiere 06202 NICE Cedex 3, France
E-mail: [email protected]
Received Date: February 14, 2012; Accepted Date: March 22, 2012; Published Date: March 26, 2012
Citation: Rubio A, Monpoux F, Bailly C, Crenesse D, Albertini M (2012) Pulmonary Function in HIV-1 Vertically Infected Children. J AIDS Clinic Res 3:146. doi:10.4172/2155-6113.1000146
Copyright: © 2012 Rubio A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Despite reports of an increasing incidence of asthma in HIV-infected children, exploration of pulmonary function by spirometry has never been reported in this population in the HAART era.
Objective: The aim of this study was to determine the prevalence of spirometric abnormalities in HIV-1 infected children. We conducted a cross-sectional study of pulmonary function tests (PFT) in HIV-1 vertically infected children.
Methods: Spirometric values were measured in 17 HIV-1 chronically infected children and compared to matched healthy children. In HIV-1 infected children, the correlations between PFT and the determination of the single breath carbon monoxide diffusing capacity of the lung (TL CO ) and immunological and virological values were assessed.
Results: Overall, 11 of the 17 PFT were normal. Four showed mild distal obstruction. Two were considered restrictive. When compared with matched healthy children, the only difference was the FEV1/FVC ratio that was significantly lower in the patients’ group (91.9% of predicted value versus 97.1%, p<0.0001). We found a positive correlation between TL CO and the CD4/CD8 T-cell ratio (p=0.012) and viral load (p=0.05). We observed that FEF 25-75 values increased with age and weight in healthy children (p= 0.006 and p=0.007 respectively), but not in infected patients.
Conclusions: Our results showed that chronic HIV-1 infection and/or continuous HAART exposure induce a specific response of the pulmonary immune system which may compromise its function with time. If confirmed, it may justify a careful follow-up of pulmonary function in vertically infected children