alexa Pulmonary Hemorrhage and Renal Involvement in Benzylthiouracil- Induced Vasculitis
ISSN: 2167-7948

Journal of Thyroid Disorders & Therapy
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Case Report

Pulmonary Hemorrhage and Renal Involvement in Benzylthiouracil- Induced Vasculitis

Hayet Kaaroud1*, Karima Boubaker1, Karima Khiari1, Hédi ben Maiz2 and Adel Kheder1
1Department of Internal Medicine a Charles Nicole Hospital, Boulevard 9 Avril, 1006 Bab Souika, Tunis, Republic of Tunisia
2Laboratory of Research in kidney Pathologies, Charles Nicolle Hospital, Boulevard 9 Avril, 1006 Bab Souika, Tunis, Republic of Tunisia
Corresponding Author : Dr. Hayet Kaaroud
Department of Internal Medicine a Charles Nicole Hospital
Boulevard 9 Avril, 1006 Bab Souika
Tunis, Republic of Tunisia
Tel: 00216 98365096
Fax: 00216 71562835
E-mail: [email protected]
Received February 28, 2012; Accepted July 17, 2012; Published July 20, 2012
Citation: Kaaroud H, Boubaker K, Khiari K, ben Maiz H, Kheder A (2012) Pulmonary Hemorrhage and Renal Involvement in Benzylthiouracil-Induced Vasculitis. Thyroid Disorders Ther 1:114. doi:10.4172/2167-7948.1000114
Copyright: © 2012 Kaaroud H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Abstract Introduction: Vasculitis is a rare complication of antithyroid drugs reported with propylthiouracil, carbimazole, methimazole and Benzylthiouracil. Benzylthiouracil –induced Vasculitis are often severe forms with renal or pulmonary involvement, which can be life-threatening if left untreated .We describe the clinical course and medical management of 2 cases of severe vasculitis with alveolar hemorrhage and renal involvement occurred in 2 patients with Graves’ disease treated by Benzylthiouracil . Cases report: A 36 and 33-year-old women with Graves’ disease developed alveolar hemorrhage and acute renal failure after respectively 36 and 144 months of Benzylthiouracil therapy. Kidney biopsy showed pauci-immune crescentic glomerulonephritis in the 2 cases. Anti Neutrophil Cytoplasmic Antibody (ANCA) was positive (P- ANCA in the first patient and c-ANCA in the second patient). The condition of the first patient improved when Benzylthiouracil was withdrawn associated with corticosteroids and immunosuppressive treatment after a follow up of 6 months. However, the second patient died by severe infection after the same treatment. Conclusion: Benzylthiouracil vasculitis is a serious complication but its prognosis is good if diagnosis and treatment are early. However mortality is related to risk of infection.

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