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ISSN: 2165-8048

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Research Article

Vitamin B and Antioxidants in Relation to Treatment Duration in Cervical Cancer Patients in Ibadan

Nwozo SO1*, Folasire AM2 and Arinola OG3
1Nutritional and Industrial Biochemistry Unit, Biochemistry Department, FBMS, College of Medicine, University of Ibadan, Ibadan, Nigeria
2Radiotherapy Department, University College Hospital (UCH), University of Ibadan, Ibadan, Nigeria
3Immnunolgy Unit, Chemical Pathology, FBMS, College of Medicine, University of Ibadan, Ibadan, Nigeria
*Corresponding Author : Nwozo SO
Nutritional and Industrial Biochemistry Unit
Biochemistry Department, FBMS, College of Medicine
University of Ibadan, Ibadan, Nigeria
Tel: +234-802-365-8268
E-mail: [email protected]; [email protected]
Received May 15, 2013; Accepted October 14, 2013; Published October 21, 2013
Citation: Nwozo SO, Folasire AM, Arinola OG (2013) Vitamin B and Antioxidants in Relation to Treatment Duration in Cervical Cancer Patients in Ibadan. Intern Med 3:127. doi:10.4172/2165-8048.1000127
Copyright: © 2013 Nwozo SO, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

In this study we evaluated the variations in vitamin B namely cyanocobalamin, folate and pyridoxine, choline,protein and glucose-6-phosphate dehydrogenase (G6PD) activity in cervical cancer patients at pretherapy, when patients showed up at the clinic and at various times after the commencement of chemotherapy and radiotherapy (using one month and two months respectively). The subjects comprised 32 patients who had visited the Department of Radiotherapy and had been diagnosed with cancer of the cervix (cervical cancer) and 32 age matched control.There was a significant (ρ<0.05) decrease in the B vitamins and choline in the different groups relative to control.There was a marked variation in plasma protein at two months compared to control and G6PD significantly decreased (ρ<0.05) at one month and two months of treatment relative to control. The study showed the relationship between low levels of vitamin B group, choline, G6PD and plasma protein with cancer progression and changes accompanying treatment and a probable need for supplementation with immune boosters during therapy.

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