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ISSN: 0975-0851

Journal of Bioequivalence & Bioavailability
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Research Article

QRAR Models for Diuretics using mixed Micellar Liquid Chromatography

Li-Ping Wu1, Cong Chen2, Cheng-Jun Sun3 and Li-Ming Ye2*

1Chengdu Women and Children Central Hospital, Chengdu, 610041, China

2West China School of Pharmacy, Sichuan University, Chengdu, 610041, China

3West China School of Public Health, Sichuan University, Chengdu, 610041, China

*Corresponding Author:
Dr. Li-Ming Ye
West China School of Pharmacy
Sichuan University
Chengdu, 610041, China
Tel: +86 028 85502305
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E-mail: [email protected]

Received Date: July 05, 2011; Accepted Date: August 25, 2011; Published Date: August 27, 2011

Citation: Wu L, Chen C, Sun C, Ye L (2011) QRAR Models for Diuretics using mixed Micellar Liquid Chromatography. J Bioequiv Availab 3: 169-173. doi: 10.4172/jbb.1000079

Copyright: © 2011 Wu L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

In this article, the capability of traditional biopartitioning micellar chromatography (BMC), using the pure Brij35 solution and the mixed micellar system of Brij35/SDS (85:15) as mobile phase respectively, under adequate experimental conditions, to describe and estimate bioactivities of diuretics, has been focused. The BMCBrij35/SDS-QRAR models can simulate the resting membrane potential and the conformation of the long hydrophilic polyoxyethylene chains remains unchanged. The predictive and interpretative ability of the chromatographic models was evaluated in terms of cross-validated data (RMSEC, RMSECV and RMSECVi). The obtained BMCBrij35/SDS-QRAR were compared with the traditional BMCBrij35-QRAR models, and better statistically models were obtained using Brij35-SDS retention data.

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