alexa QSAR and Synthesis of a Novel Biphenyl Carboxamide Anal
ISSN: 2329-6798

Modern Chemistry & Applications
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Research Article

QSAR and Synthesis of a Novel Biphenyl Carboxamide Analogue for Analgesic Activity

Prasanna Datar*
Sinhgad Institute of Pharmacy, Narhe, Pune, Maharashtra, India
Corresponding Author : Prasanna Datar
Sinhgad Institute of Pharmacy
Narhe, Pune, 411041
Maharashtra, India
Tel: 91-9823-161-187
E-mail: [email protected]
Received January 21, 2015; Accepted January 20, 2015; Published January 25, 2015
Citation: Datar P (2015) QSAR and Synthesis of a Novel Biphenyl Carboxamide Analogue for Analgesic Activity. Mod Chem appl 3:148. doi: 10.4172/2329-6798.1000148
Copyright: ©2015 Datar P. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

A compound 2-(anilino)-1-(4-phenylphenyl)ethanone was synthesized by reaction between biphenyl acid chloride and aniline. The synthesized compound was screened for analgesic activity. The selection of the compound was on the basis of QSAR study performed on the biphenyl analogs having anti-inflammatory activity. 2D QSAR study using topological descriptors revealed the important features required for the design of new potent anti-inflammatory agent. QSAR equation found in present study had r2 of 0.842 and internal predictivity of 0.69. Using QSAR results a molecule was designed to have analgesic activity.

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