alexa QSAR Studies of 3, 4-dihydropyrimidin-2(1H)-one Urea Derivatives as Antibacterial and Antifungal activity | OMICS International | Abstract
ISSN: 2157-7420

Journal of Health & Medical Informatics
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Research Article

QSAR Studies of 3, 4-dihydropyrimidin-2(1H)-one Urea Derivatives as Antibacterial and Antifungal activity

Mukesh C. Sharma*

School of Pharmacy, Devi Ahilya University, Takshila Campus, Khandwa Road, Indore-452001, MP, India

*Corresponding Author:
Mukesh C. Sharma
School of Pharmacy, Devi Ahilya University
Takshila Campus, Khandwa Road
Indore-452001, MP, India
Tel: 91- 731-216005
E-mail: [email protected]

Received date: April 17, 2015; Accepted date: June 10, 2015; Published date: June 17, 2015

Citation: Sharma MC (2015) QSAR Studies of 3, 4-dihydropyrimidin-2(1H)-one Urea Derivatives as Antibacterial and Antifungal activity. J Health Med Informat 6:191. doi:10.4172/2157-7420.1000191

Copyright: © 2015 Sharma MC. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The present study is aimed to elucidate the structural features of novel 3,4-dihydropyrimidin-2(1H)-one urea derivatives required for antibacterial and antifungal activity and to obtain predictive models to guide the rational synthesis of novel activity. The significant best 2D QSAR model (S.aureus) having correlation coefficient r2 = 0.7854 and crossvalidated squared correlation coefficient q2 = 0.7563 with external predictive ability of pred_r2 = 0.7629 was developed. The main aimed to obtain predictive models which may guide the synthesis of more active antimicrobial agents.

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