alexa Qualitative and Quantitative Analysis of Dan-Deng-Tong-Nao Capsules by HPLC-DAD-MS/MS
ISSN: 2469-9861

Mass Spectrometry & Purification Techniques
Open Access

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Research Article

Qualitative and Quantitative Analysis of Dan-Deng-Tong-Nao Capsules by HPLC-DAD-MS/MS

Yunliang Zheng, Xingjiang Hu, Meihua Lin, You Zhai, Lihua Wu and Jianzhong Shen-Tu*

Research Center for Clinical Pharmacy, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, Zhejiang University, Hangzhou, PR China

*Corresponding Author:
Jianzhong Shen-Tu
Research Center for Clinical Pharmacy
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases
First Affiliated Hospital, Zhejiang University
79# Qingchun Road, Hangzhou 310003, PR China
Tel: 86-571-87236537
E-mail: [email protected]

Received date: February 19, 2016; Accepted date: February 29, 2016; Published date: March 05, 2016

Citation: Zheng Y, Hu X, Lin M, Zhai Y, Wu L, et al. (2016) Qualitative and Quantitative Analysis of Dan-Deng-Tong-Nao Capsules by HPLC-DAD-MS/MS. Mass Spectrom Purif Tech 2:110. doi:10.4172/2469-9861.1000110

Copyright: © 2016 Zheng Y. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



This review article discussed application of ionic liquids as matrices (ILMs) for mass spectrometry (MS). ILMs were applied for matrix assisted laser desorption/ionization, (ILMALDI-MS), electrospray ionization (ILMs-ESI-MS) and desorption corona beam ionization (DCBI-MS). Ionic liquids matrices provided several advantages such as low vapor pressure, have high stability for storage and under vacuum, extremely high sensitivity and showed low background or interferences. They are non-explosive, non-flammable and are thermally stable. The materials are promising for real measurements and require further investigations to improve the current performance. The combination between the conventional matrices and organic bases leaded to high ionization performance. The proton transfer efficiency of ILMs is higher than conventional matrices as the proton take place from the salt form. They were applied for many analytes such as biomarker, protein, peptides, polymers (synthetic and nature), small organic compounds and pharmaceuticals drugs.


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