alexa Quality Verification of Dendritic Cell-Based Cancer Vaccine | OMICS International | Abstract
ISSN : 2153-2435

Pharmaceutica Analytica Acta
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Quality Verification of Dendritic Cell-Based Cancer Vaccine

Shigetaka Shimodaira1*, Terutsugu Koya1, Yumiko Higuchi1, Masato Okamoto2 and Shigeo Koido3

1Center for Advanced Cell Therapy, Shinshu University Hospital, Matsumoto, Nagano 390-8621, Japan

2Department of Advanced Immunotherapeutics, Kitasato University School of Pharmacy, Minato-ku 108-8641, Tokyo, Japan

3Department of Gastroenterology and Hepatology, The Jikei University School of Medicine, Kashiwa, Chiba 277-8567, Japan

*Corresponding Author:
Shigetaka Shimodaira
Center for Advanced Cell Therapy
Shinshu University Hospital 3-1-1 Asahi
Matsumoto, Nagano 390-8621, Japan
Tel: +81-263-37-3580
Fax: +81-263-37-3027
E-mail: [email protected]

Received Date: January 30, 2016; Accepted Date: February 16, 2016; Published Date:February 18, 2016

Citation: Shimodaira S, Koya T, Higuchi Y, Okamoto M, Koido S (2016) Quality Verification of Dendritic Cell-Based Cancer Vaccine. Pharm Anal Acta 7:465.doi: 10.4172/2153-2435.1000465

Copyright: © 2016 Shimodaira S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

In the era of personalized cancer therapy, immunotherapy is now emerging as a potential option. Therapeutic cancer vaccination has been developed for the induction of an efficient immune response targeting tumor-associated antigens. The efficacy of dendritic cell (DC)-based vaccines is attributed to their ability to induce immunity against cancers. Criteria for the approval of therapeutically active DCs, such as their viability and purity, are here verified based on phenotypic characteristics, linked to their antigen-presenting ability and functional analyses of phagocytosis and pinocytosis. A standardized phenotype of DCs harboring bioactive functions would be useful to provide personalized vaccines for cancer immunotherapy.

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