alexa Quantification of Doxycycline in Raw Material by an Eco
ISSN : 2153-2435

Pharmaceutica Analytica Acta
Open Access

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Research Article

Quantification of Doxycycline in Raw Material by an Eco-Friendly Method of Infrared Spectroscopy

Ana Carolina Kogawa*, Natalia Prudente de Mello and Hérida Regina Nunes Salgado

Department of Pharmaceutics, School of PharmaceuticalSciences of Araraquara, Univ Estadual Paulista - UNESP, Araraquara, São Paulo, Brazil

*Corresponding Author:
Ana Carolina Kogawa
Programa de Pós-graduação em Ciências Farmacêuticas
Faculdade de Ciências Farmacêuticas de Araraquara
UNESP, Rodovia Araraquara-Jaú, km 1, CEP 14801-902, Araraquara, SP, Brazil
Tel: +55 16 3301 4681
Fax: +55 16 3301 6967
E-mail: [email protected]

Received Date: February 02, 2016; Accepted Date: February 23, 2016;Published Date:February 25, 2016

Citation: Kogawa AC, de Mello NP, Salgado HRN (2016) Quantification of Doxycycline in Raw Material by an Eco-Friendly Method of Infrared Spectroscopy. Pharm Anal Acta 7:463. doi: 10.4172/2153-2435.1000463

Copyright: © 2016 Kogawa AC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Doxycycline is a broad spectrum antibiotic used in the treatment of infectious diseases in humans and animals. It is distributed free of charge, by medical prescription, in Brazil through the public health system. Thus, since a considerable number of people have access to this drug, it is of great interest to control its quality. The purpose of the research was the development and validation of an eco-friendly method by Fourier-Transform Infrared (FT-IR) transmission spectroscopy for the determination of doxycycline in raw material. The raw material quality directly determines the quality of the drug. Through this analysis the method was completely validated according to the International Conference on Harmonization guidelines, showing accuracy, precision, selectivity, robustness and linearity. It was linear over the concentration range of 0.5 – 2.5 mg with correlation coefficient 0.9991 and limits of detection and quantification of 0.125 and 0.378 mg, respectively. Fourier-Transform Infrared (FT-IR) transmission spectroscopy method is considered environmentally friendly because it uses only the potassium bromide as reagent, which is cheap and safe for the operator, does not expose the operator to toxic solvents or harmful reagents, and optimizes equipment for being a rapid analysis. The validated method is useful to the routine quality control of doxycycline.

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