alexa Quantitative Analysis of a Dynamic Cell Cycle Regulatory Model of Schizosaccharomyces pombe | OMICS International | Abstract
ISSN: 2332-0737

Current Synthetic and Systems Biology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Quantitative Analysis of a Dynamic Cell Cycle Regulatory Model of Schizosaccharomyces pombe

Anbumathi P*, Sharad Bhartiya and KV Venkatesh

Department of Chemical Engineering, Indian Institute of Technology Bombay, Mumbai, India

*Corresponding Author:
Anbumathi P
School of Chemical and Biotechnology
SASTRA University, Thanjavur, 613401, India
Tel: +91-4362-264101-108 Extn: 3657
E-mail: [email protected]

Received date: June 24, 2013; Accepted date: September 10, 2013; Published date: September 12, 2013

Citation: Anbumathi P, Bhartiya S, Venkatesh KV (2013) Quantitative Analysis of a Dynamic Cell Cycle Regulatory Model of Schizosaccharomyces pombe. Curr Synthetic Sys Biol 1:105. doi: 10.4172/2332-0737.1000105

Copyright: © 2013 Anbumathi P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Cell cycle is the central process that regulates growth and division in all eukaryotes. Based on the environmental condition sensed, the cell lies in a resting phase G0 or proceeds through the cyclic cell division process (G1->S->G2- >M). These series of events and the irreversible phase transitions are governed mainly by the highly conserved Cyclin dependent kinases (Cdks) and its positive and negative regulators which results in a highly interconnected network. The dynamics of the cell cycle regulation is due to this underlying complex network that governs this process. In in silico models it is the parameter set that directly reflects the characteristics of the system. Synthesis rate constants indirectly represent the source of complexity. Therefore, a recently developed model for fission yeast Schizosaccharomyces pombe cell cycle regulation was utilized to investigate the influence of synthesis level regulation on the overall cell cycle period. A systematic local and the global perturbation of sixteen synthesis rate constants of the model were performed to study the synthesis level influence of these regulators on (i) viability, (ii) cell cycle period and (iii) robustness. The results of sensitivity analysis indicates that the cell cycle time is robust to perturbation in the synthesis rate constant of single regulators but fragile to simultaneous perturbation of the multiple regulators. In addition, a perspective on emergence of robustness with respect to multiple layers of complex regulators over a fragile core network is demonstrated based on a systematic regulator deletion and addition analysis. Some of the key predictions that emerge from this study includes, that (i) seven regulatory components Slp1, Cdc2, Cdc13, PP1, APC, and Cdc25 along with Mik1 or Wee1 are sufficient to drive cell cycle regulation. This can be verified by designing appropriate synthetic biology experiments; (ii) either one of the G2 regulatory kinases Wee1 or Mik1 could have emerged through whole chromosome duplication events during evolution which can be tested experimentally to arrive with a conclusive proof.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

bornova escort

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

https://www.gaziantepescort.info

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7