alexa Quantitative Profiling of Histone H3 Methylation in Human Hepatocellular Carcinoma | OMICS International
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Quantitative Profiling of Histone H3 Methylation in Human Hepatocellular Carcinoma

Jiajia Chen1,2, Guoquan Yan1, Fang Wang1,2, Xuefei Yin1,2, Hong Jin1,2* and Peng-yuan Yang1,2*

1Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China

2Institute of Biomedical Science, Fudan University, 138 Yixueyuan Road, Shanghai, 200032, China

*Corresponding Author:
Hong Jin
Department of Chemistry
Fudan University
220 Handan Road
Shanghai 200433, China
Tel: 0086 2154237664
Fax:0086 21 54237961
E-mail: [email protected]

Peng-yuan Yang
Institute of Biomedical Science
Fudan University, 138 Yixueyuan
Road, Shanghai, 200032, China
Tel: 0086 2165642009
Fax:0086 21 65642009
E-mail: [email protected]

Received Date: May 10, 2013; Accepted Date: June 10, 2013; Published Date: June 13, 2013

Citation: Chen J, Yan G, Wang F, Yin X, Jin H, et al. (2013) Quantitative Profiling of Histone H3 Methylation in Human Hepatocellular Carcinoma. J Proteomics Bioinform S2: 003. doi:10.4172/jpb.S2-003

Copyright: © 2013 Chen J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Alterations of epigenetics including DNA methylation and histone modifications play crucial roles in both initiation and progression of certain types of cancers. Abnormal histone modifications identified within these tumors represent potential biomarkers and therapeutic pathways. In this study, two different types of human hepatocellular carcinoma cell lines HepG2 and MHCC97-H with distinct metastasis capability are used to investigate the association of liver metastasis with cellular histone modification levels. In the HepG2 and MHCC97-H cells, 17 types of histone H3 modification corresponding to methylation are quantitatively profiled with LC coupled to high resolution mass spectrometry. Compared to HepG2 cells without metastasis capability, the combinatorial histone peptides of K9me1K14ac and K9me0K14ac in malignant MHCC97-H cells are found to be significantly down regulated, while the level of H3K9me3 and H3K27me2 are greatly increased. Overall these data provide novel insights into the histone methylation regulatory mechanism in liver metastasis and reveal the epigenetic pathway for HCC disease development.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version