alexa Quantitative Radioiodine Treatment of Graves' Hyperthyr
ISSN: 2167-7948

Journal of Thyroid Disorders & Therapy
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Research Article

Quantitative Radioiodine Treatment of Graves' Hyperthyroidism Using Different Intended Activities and the Same Weighting Factor

Shiwei Sheng1, Yang Wang1, Maomei Ruan1, Tao Ying2 and Libo Chen1*
1Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, People’s Republic of China
2Department of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, P.R. China
Corresponding Author : Libo Chen
Department of Nuclear Medicine
Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Shanghai 200233, People’s Republic of China
600 Yishan Road, Shanghai 200233, P.R. China
Tel: 86-21-64369181
Fax: 86-21-64701361
E-mail: [email protected]
Received March 11, 2014; Accepted April 11, 2014; Published April 13, 2014
Citation: Sheng S, Wang Y, Ruan M, Ying T, Chen L (2014) Quantitative Radioiodine Treatment of Graves' Hyperthyroidism Using Different Intended Activities and the Same Weighting Factor. Thyroid Disorders Ther 3:157. doi:10.4172/2167-7948.1000157
Copyright: © 2014 Sheng S et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Context: There is little consensus on the most appropriate dose regimen for radioiodine treatment (RIT) of Graves’ hyperthyroidism (GH), and quantitative studies on the role of the efficacy-affecting parameters are lacking.
Objective: This prospective study was designed to evaluate the feasibility of quantitative RIT of GH using a modified formula, which took into account eight parameters associated with the outcome.
Design: A 1-year follow-up study of 205 GH patients was performed.
The administered activity of 131I was established using a formula,
Activity MBq = [(gland weight (g) ×in tended activity) (MBq/g) /Max uptake] (% )× (1 + X/30) in which the X represented the sum of the parameters, and the administered activity increased or decreased by 1/30 when each of the parameters was present or absent. The subjects were randomized into two groups according to the intended activity.
Results: No significant differences at baseline were noted between the two groups. The mean administered activity of 131I in 3.7 MBq/g group was significantly lower than that in 5.55 MBq/g group. One year after therapy, 77.6% patients were treated successfully, with 76.3% in the 3.7 MBq/g group (58.8% achieved euthyroidism, 17.5% became hypothyroid) and 78.7% in the 5.55 MBq/g group (38.9% achieved euthyroidism, 39.8% became hypothyroid). Hypothyroidism occurred earlier in the 5.55 MBq/g group with rates significantly higher than those in the 3.7 MBq/g group.
Conclusions: The modified formula seems feasible in the RIT of GH, which takes into account the quantification of efficacy-affecting parameters. The intended activity of 5.55 MBq/g may result in a higher rate of hypothyroidism and an earlier cure of hyperthyroidism than the activity of 3.7 MBq/g, which appears to be more favorable for maintaining euthyroidism.

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