alexa Quantum Dots Conjugated with Transferrin for Brain Tumor Cell Imaging
ISSN: 2157-7013

Journal of Cell Science & Therapy
Open Access

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Research Article

Quantum Dots Conjugated with Transferrin for Brain Tumor Cell Imaging

Hiroshi Yukawa1*, Ryoko Tsukamoto1, Ayano Kano2, Yukihiro Okamoto1, Manabu Tokeshi4, Tetsuya Ishikawa2, Masaaki Mizuno5,6 and Yoshinobu Baba1,3,7
1FIRST Research Center for Innovative Nanobiodevices, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan
2Department of Medical Technology, Nagoya University, Graduate School of Medicine, Daikominami, Higashi-ku, Nagoya 461-8673, Japan
3Department of Applied Chemistry, Nagoya University Graduate School of Engineering, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan
4Division of Biotechnology and Macromolecular Chemistry, Faculty of Engineering, Kita 13, Nishi 8, Kita-ku, Sapporo 060-8628, Japan
5Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Tsurumai-cho, Showa-ku, Nagoya 466-8650, Japan
6Strong Care Managing Center, Nagoya University Hospital, Tsurumai-cho, Showa-ku, Nagoya 466-8650, Japan
7Health Technology Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Hayashi-cho 2217-14, Takamatsu 761-0395, Japan
Corresponding Author : Hiroshi Yukawa
FIRST Research Center for Innovative Nanobiodevices
Nagoya University, Furo-cho
Chikusa-ku, Nagoya 464-8603, Japan
Tel: +81-52-789-5654
Fax: +81-52-789-3560
E-mail: [email protected]
Received November 05, 2013; Accepted November 28, 2013; Published December 02, 2013
Citation: Yukawa H, Tsukamoto R, Kano A, Okamoto Y, Tokeshi M, et al. (2013) Quantum Dots Conjugated with Transferrin for Brain Tumor Cell Imaging. J Cell Sci Ther 4: 150. doi: 10.4172/2157-7013.1000150
Copyright: © 2013 Yukawa H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Malignant brain cancers derived from the cerebral parenchyma are difficult to remove completely due to the impossibility of eliminating the entire cancerous area, thus the eradicating brain cancer at the cellular level is strongly desired in order to obtain a good prognosis. In this study, we assessed the efficiency of Quantum Dots (QDs) conjugated with Transferrin (Tf) (QDs-Tf) for specific imaging of cancer cells. The expression of Transferrin Receptor (TfR) was confirmed on the surface of U87 cells (human glioblastoma cells, a major type of malignant brain cancer cells) at a high level; however the expression in NHA (a normal human astrocyte cell line) was extremally low. The labeling efficiency of U87 cells by QDs-Tf was 99.8%, while that of QDs alone was 8.4%. In addition, the red fluorescence derived from U87 cells labeled with QDs-Tf was clearly detected and the intensity was maintained for at least two days. These data suggest that imaging glioblastoma cells using QDs-Tf is useful for the detecting cancer at the cellular level with clinical applications

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