Radiance Spectroscopy Tool Box for Characterizing Au Nanoparticles in Tissue Mimicking Phantoms as Applied to Prostate
- *Corresponding Author:
- Serge Grabtchak
Department of Physics
University of Prince Edward Island
550 University Avenue, Charlottetown
PEI C1A 4P3 Canada
E-mail: [email protected]
Received Date: October 24, 2011; Accepted Date: November 28, 2011; Published Date: November 30, 2011
Citation: Grabtchak S, Palmer TJ, Whelan WM (2011) Radiance Spectroscopy Tool Box for Characterizing Au Nanoparticles in Tissue Mimicking Phantoms as Applied to Prostate. J Cancer Sci Ther S1:008. doi:10.4172/1948-5956.S1-008
Copyright: © 2011 Grabtchak S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: We have developed a new approach to map localized inclusions of gold nanoparticles in the Intralipid-1% liquid phantom. Our goal was to show that combined spectroscopic and angular snapshots of liquid phantoms and phantoms with inclusions allow obtaining information relevant for prostate cancer diagnostics and treatment.
Methods: A combination of the point radiance spectroscopy and white light spectroscopy was used to measure angular resolved light distribution in 450-900 nm spectral range in Intralipid-1% liquid phantoms with and without localized inclusions of gold nanoparticles.
Results: Characteristic spectro-angular snapshots of the liquid phantom alone and with the localized inclusion of gold nanoparticles were obtained. For liquid phantoms without inclusions, the snapshots demonstrate wavelength dependent light distribution inside the turbid medium, visualize the transparency window and provide a quantification of angular spread of different wavelengths of light. For liquid phantoms with gold inclusions, the approach allows to isolate the spectroscopic signatures of the inclusions from the background, identify locations of the inclusions in the angular domain and quantify the detection limits in terms of the contrast value attainable for the selected quantity of gold nanoparticles located at the specific depth in tissue. A detection of 3x10 13 particles up to 25 mm deep in Intralipid-1% was demonstrated.
Conclusions: The encouraging results indicate a promising potential of radiance spectroscopy in prostate treatment and diagnostics with gold nanoparticles.