Radiation Therapy in Optic Gliomas: A Case Report and a Review of LiteratureFedele D*, Ponti E, Tolu B, Ingrosso G, Hamoud E, Terenzi S, Tortorelli G And Santoni R
Department of Diagnostic Imaging, Molecular Imaging, Interventional Radiology and Radiotherapy, Tor Vergata University General Hospital, Rome, Italy
- *Corresponding Author:
- Dahlia Fedele
Department of Diagnostic Imaging
Molecular Imaging, Interventional Radiology and Radiotherapy
Tor Vergata University General Hospital, Rome, Italy
E-mail: [email protected]
Received date: July 02, 2012; Accepted date: July 25, 2012; Published date: July 27, 2012
Citation: Fedele D, Ponti E, Tolu B, Ingrosso G, Hamoud E, et al. (2012) Radiation Therapy in Optic Gliomas: A Case Report and a Review of Literature. J Nucl Med Radiat Ther 3:134. doi:10.4172/2155-9619.1000134
Copyright: © 2012 Dahlia F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
To assess the role of Radiation Therapy (RT), in the treatment of optic glioma analyzing 11 retrospective trials during the latest twenty-five years.
In a 25-year-old woman, referred to our centre because of right optic glioma, fractionated stereotactic radiation therapy (FSRT) was the treatment of choice using a commercial linear accelerator Elekta Synergy beam modulator with an integrated Cone Beam Computed Tomography (CBCT) system. In order to evaluate volumetric changes of the right optic nerve lesion a co-registration of pre-RT Magnetic Resonance Imaging (MRI) and CT planning scan was performed and compared with the co-registration of CT planning scan and MRI performed 3 years after the end of the treatment. A noticeable shrinkage in Clinical Target Volume was found and the patient experienced a complete recovery of the right eye visual deficit.
Successful Progression Free Survival and Overall Survival at 10 years can be obtained using a dose between 52 and 60 Gy. FSRT is advantageous compared to conventional RT because of sparing of normal tissues within the high dose volume. Modern linear accelerators with an integrated Cone Beam system improve treatment set-up and dose delivery