alexa Radiation-Induced Glioblastoma Following Radiotherapy for Pituitary Adenomas: Marked Response to Chemotherapy
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

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Case Report

Radiation-Induced Glioblastoma Following Radiotherapy for Pituitary Adenomas: Marked Response to Chemotherapy

Takashi Kon1,2, Manabu Natsumeda1, Hitoshi Takahashi3, Tomohiko Taki4,Yukihiko Fujii1, and Ryuya Yamanaka5*

1Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan

2Department of Neurosurgery, Kariwa County General Hospital, Niigata, Japan

3Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan

4Department of Molecular Diagnostics and Therapeutics, Kyoto Prefectural University of Medicine, Kyoto, Japan

5Graduate School for Health Care Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

Corresponding Author:
Ryuya Yamanaka
Kyoto Prefectural University of Medicine
Graduate School for Health Care Science
Kyoto 602-8566, Japan
Tel: +81-75-212-5429
Fax: +81-75-212-5423
E-mail: [email protected]

Received date: July 03, 2013; Accepted date: July 17, 2013; Published date: July 25, 2013

Citation: Kon T, Natsumeda M, Takahashi H, Taki T,Fujii Y (2013) Radiation-Induced Glioblastoma Following Radiotherapy for Pituitary Adenomas: Marked Response to Chemotherapy. J Neurol Neurophysiol 4:155. doi:10.4172/2155-9562.1000155

Copyright: © 2013 Kon T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Radiation-induced glioblastoma is particularly resistant to treatment, and therapeutic options are limited. We report a 48-year-old woman with a radiation-induced glioblastoma who had a complete response to nimustine hydrochloride. Our patient developed a left temporal meninigioma 22 years after and bi-temporal glioblastoma 30 years after a pituitary adenoma was treated with surgery and 50 Gy radiation therapy. She was treated with subtotal resection followed by four cycles of nimustine hydrochloride; a complete response was achieved. She relapsed 16 months after diagnosis of glioblastoma, and underwent further surgery and treatment with temozolomide. She survived for 26
months after the onset of glioblastoma. As the site was within the irradiated area, both meninigioma and glioblastoma were thought to be radiation-induced tumors. If further radiotherapy is not a therapeutic option for glioblastoma, chemotherapy may result in prolonged survival.


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