Radiochemical and Biological Evaluation of 99mTc-Labeling of Phthalic Acid Using 99mTc-Tricabonyl and 99mTc-Sn (II) As a Model for Potential Hazards Imaging
- *Corresponding Author:
- Sanad MH
Labelled Compounds Department, Hot Labs Center
Atomic Energy Authority, P.O. Box 13759
E-mail: [email protected]
Received date: July 11, 2016; Accepted date: October 25, 2016; Published date: October 28, 2016
Citation: Sanad MH, Saad MM, Fouzy ASM, Marzook F, Ibrahim IT (2016) Radiochemical and Biological Evaluation of 99mTc-Labeling of Phthalic Acid Using 99mTc-Tricabonyl and 99mTc-Sn (II) As a Model for Potential Hazards Imaging. J Mol Imag Dynamic 6: 126. doi:10.4172/2155-9937.1000126
Copyright: © 2016 Sanad MH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
In this study, 99mTc- phthalic acid (PA) firstly, was prepared with a high radiochemical yield up to 98% that confirmed with different chromatographic techniques by using 2 mg phthalic acid, 50 μg SnCl2·2H2O as a reducing agent, in solution of pH 7 at room temperature for 30 min. Secondly, 99mTc-tricarbonyl phthalic acid was prepared under 30 min heating at 100°C. Bio distribution studies were carried out in Albino Swiss mice in which 99mTc-PA and 99mTc-tricarbonyl PA were concentrated in kidneys and intestine. This work aims to evaluation of labeled PA as a model for Potential Hazards imaging in vitro and in vivo toxicity in Albino Swiss mice.