alexa Randomized Controlled Trial on the Use of Intravenous Immune Globulin in Acute Pediatric Myocarditis
ISSN: 2155-9627

Journal of Clinical Research & Bioethics
Open Access

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Research Article

Randomized Controlled Trial on the Use of Intravenous Immune Globulin in Acute Pediatric Myocarditis

Sonia Ali El-Saiedi*

Cairo University, Cairo, Egypt

*Corresponding Author:
Sonia Ali El-Saiedi
Cairo University, Cairo, Egypt
E-mail: [email protected]

Received Date: October 17, 2013; Accepted Date: November 28, 2013; Published Date: December 07, 2013

Citation: El-Saiedi SA (2013) Randomized Controlled Trial on the Use of Intravenous Immune Globulin in Acute Pediatric Myocarditis. J Clin Res Bioeth 5:170. doi: 10.4172/2155-9627.1000170

Copyright: © 2013 El-Saiedi SA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: Myocardial damage in myocarditis is mediated, in part, by immunological mechanisms. This prospective placebo controlled trial was designed to determine whether Intravenous Immune Globulin (IVIG) improves Left Ventricular Fractional Shortening (LVFS) and decrease left ventricular end diastolic volume (LVED) in children with acute onset dilated cardiomyopathy or myocarditis.

Methods: 86 patients were enrolled in the study all presenting with recent onset dilated cardiomyopathy duration less than 6 months. They were randomized to 2 g/kg IVIG over two consecutive days or placebo. All underwent echocardiographic examination before admission then one month and six months after randomization. Each time the left ventricular end diastolic dimension (LVEDD) and fractional shortening (FS) were recorded.

Results: At baseline the LVEDD and FS did not differ significantly between those treated with IVIG and those treated with Placebo. Over the period of six months follow-up the patients in both groups became better. Patients treated with conventional therapy continued to have a mean end diastolic dimensions significantly larger than treated children, with no evidence of regression.

Conclusion: The results suggest that for young patients with recent onset dilated cardiomyopathy, IVIG does not augment the improvement in left ventricular FS. However, in this overall cohort, left ventricular FS improved significantly with time during follow up.

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