alexa Randomized Double Blind Control Study Comparing the Eff
ISSN: 2155-6148

Journal of Anesthesia & Clinical Research
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Randomized Double Blind Control Study Comparing the Efficacy of Intracuff Alkalinized Lidocaine to Low Dose Remifentanil Infusion in Attenuating the Endotracheal Tube Induced Emergence Phenomena

Rashmi Vandse*, Karina Castellon-Larios, Jeffrey Fujii, Somayah Melibary, Lai Wei, Sherry Nashed and Sergio Bergese

Department of Anesthesiology, Wexner Medical Center, Ohio State University, Columbus, OH, USA

*Corresponding Author:
Rashmi Vandse
Department of Anesthesiology, Wexner Medical Center
The Ohio State University
Doan Hall N 416, 410 W 10th Ave.
Columbus, OH. 43210, USA
Tel:(614) 293-8487
Fax:(614) 293-8153
E-mail: [email protected]

Received date: August 07, 2014; Accepted date: September 15, 2014; Published date: September 22, 2014

Citation: Vandse R, Castellon-Larios K, Fujii J, Melibary S, Wei L, et al. (2014) Randomized Double Blind Control Study Comparing the Efficacy of Intracuff Alkalinized Lidocaine to Low Dose Remifentanil Infusion in Attenuating the Endotracheal Tube Induced Emergence Phenomena. J Anesth Clin Res 5:435. doi: 10.4172/2155-6148.1000435

Copyright: © 2014 Vandse R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Emergence from general anesthesia is often complicated by the endotracheal tube (ETT) induced airway and circulatory reflexes which can lead to potentially dangerous complications. Considerable research has been focused on prevention of these emergence phenomena (EP). Nevertheless, the problem is still far from its final solution.

Objective: To compare the efficacy of intracuff alkalinized lidocaine (ICL) vs low dose remifentanil infusion in attenuating the ETT-induced EP. Methods: 120 ASA I-III patients, aged 18-65 years, were randomly assigned to receive intracuff alkalinized lidocaine (2% lidocaine mixed 1:1 with 1.4% NaHCO3) or an intravenous (IV) remifentanil infusion (0.05-0.5 mcg/ kg/min) combined with intracuff saline during desflurane-based general anesthesia. At the end of surgery, after desflurane was turned off in the assigned group, low dose remifentanil, or its equivalent placebo was decreased to one-tenth of the mean dose but not less than 0.01 mcg/kg/min and it was continued until extubation. A blinded researcher observed each patient from the time desflurane was discontinued until at least five minutes after extubation. Coughing was evaluated as either present or not, and graded on a point scale based on severity. The patients were also observed for development of any adverse events along with the vital signs during this emergence phase.

Results: The incidence (44% vs 67%, p=0.02) and severity of coughing, overall, was significantly less in the lidocaine group compared to remifentanil group). The lidocaine group also had a lower incidence of significant coughing (2-3 on point scale) (25% vs 49%, p=0.009). The mean arterial pressure (MAP) in the lidocaine group was lower than the remifentanil group at extubation and 5 minutes after extubation.

Conclusions: Intracuff alkalinized lidocaine (ICL) is more effective in reducing the incidence and severity of coughing compared to a low dose remifentanil infusion during emergence from desflurane based anesthesia

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords