alexa Randomized Intra-patient Controlled Trial of Mepilex Lite Dressings versus Aqueous Cream in Managing Radiation-Induced Skin Reactions Postmastectomy | OMICS International | Abstract
ISSN: 1948-5956

Journal of Cancer Science & Therapy
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Research Article

Randomized Intra-patient Controlled Trial of Mepilex Lite Dressings versus Aqueous Cream in Managing Radiation-Induced Skin Reactions Postmastectomy

Dean B Paterson1, Prashika Poonam2, Noelle C Bennett3, Ruth I Peszynski3, Meredith J Van Beekhuizen4, Marieke L Jasperse5 and Patries M Herst5*

1Wellington Blood and Cancer Centre, Wellington Hospital, Wellington, New Zealand

2Regional Cancer Treatment Service, Palmerston North Hospital, Palmerston North, New Zealand

3Radiation Oncology Department, Southern Blood and Cancer Centre, Dunedin Hospital, P.O. Box 1921, Dunedin, New Zealand

4Auckland Radiation Oncology, 98 Mountain Rd, Epsom, Auckland 1023, New Zealand

5Department of Radiation Therapy, University of Otago, Wellington, P.O. Box 7343, Wellington, New Zealand

*Corresponding Author:
PM Herst
Department of Radiation Therapy
University of Otago, Wellington
P.O. Box 7343, Wellington, New Zealand
Tel: 6443855475
Fax: 6443855375
E-mail: [email protected]

Received date: August 31, 2012; Accepted date: September 26, 2012; Published date: September 28, 2012

Citation: Paterson DB, Poonam P, Bennett NC, Peszynski RI, Van Beekhuizen MJ, et al. (2012) Randomized Intra-patient Controlled Trial of Mepilex Lite Dressings versus Aqueous Cream in Managing Radiation-Induced Skin Reactions Post-mastectomy. J Cancer Sci Ther 4: 347-356. doi:10.4172/1948-5956.1000166

Copyright: © 2012 Paterson DB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Objective: Severe acute radiation-induced skin reactions occur in a significant proportion of women who receive radiation therapy for breast cancer. We previously showed that Mepilex Lite dressings decreased the severity of erythema. Here we report their effect on the full range of skin reactions in 74 breast cancer patients post-mastectomy.
Methods: A total of 80 women were recruited from four hospitals in New Zealand with 74 women contributing a full data set for analysis. The first skin area on the chest wall to develop erythema was randomly divided into two similar halves; one half was treated with Mepilex Lite dressings, the other half with aqueous cream. Skin reactions were assessed using the Radiation-Induced Skin Reaction Assessment Scale.
Results: Compared with aqueous cream, Mepilex Lite dressings did not significantly reduce the incidence of moist desquamation but did reduce the overall severity of skin reactions by 41% (p<0.001), the average moist desquamation score by 49% (p=0.043) and the sum of the moist desquamation time for all patches by 28% from 25 to 18 weeks. Most patients preferred the dressings, found them easy to use and very comfortable to wear.


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