alexa Randomized Trial of Repetitive Transcranial Magnetic Stimulation for Apathy and Depression in Parkinson’s Disease
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

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Research Article

Randomized Trial of Repetitive Transcranial Magnetic Stimulation for Apathy and Depression in Parkinson’s Disease

Hiroaki Oguro1*, Tomonori Nakagawa1, Shingo Mitaki1, Masaki Ishihara2, Keiichi Onoda1 and Shuhei Yamaguchi1

1Department of Neurology, Faculty of Medicine, Shimane University, Shimane, Japan

2Department of Neurology, Tokyo Metropolitan Health and Medical Treatment Corporation, Toshima Hospital, Tokyo, Japan

Corresponding Author:
Hiroaki Oguro
89-1 Enya-cho
Izumo, Shimane 693-8501, Japan
Tel: +81-853-20-2199
E-mail: [email protected]

Received date: August 20, 2014; Accepted date: October 27, 2014; Published date: October 31, 2014

Citation: Oguro H, Nakagawa T, Mitaki S, Ishihara M, Onoda K, et al (2014) Randomized Trial of Repetitive Transcranial Magnetic Stimulation for Apathy and Depression in Parkinson’s Disease. J Neurol Neurophysiol 5:242. doi:10.4172/2155-9562.1000242

Copyright: © 2014 Oguro H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Objective: Repetitive transcranial magnetic stimulation (rTMS) has been reported to improve motor function and depression in Parkinson’s disease (PD) patients, but there has been only one randomized controlled trial for apathy. We evaluated the efficacy of rTMS for apathy and depression in Parkinson’s disease. Methods: Fifteen PD patients received real rTMS (5 Hz, 500 pulses/day) and placebo stimulation over the supplementary motor area (SMA) for each 5 days with total amount of 2500 real pulses and 2500 placebo pulses, using a randomized real-first or placebo-first protocol. The modified apathy scale, the Zung Self-rating Depression Scale (SDS) and Unified Parkinson’s Disease Rating Scale (UPDRS) were used to assess apathy, depression and clinical status before and after each stimulative treatment. Results: Real rTMS improved the apathy score by 3 points (P<0.05) compared to the baseline, while placebo stimulation produced no improvement, irrespective of the order of treatment. Real rTMS also improved the depression scale, SDS by 5 points (P<0.05) compared to the baseline, while placebo stimulation was ineffective. Combined analysis confirmed that real rTMS was significantly superior to placebo stimulation in apathy and depression (p<0.05). Real rTMS also improved UPDRS by 10 points (P=0.001), while placebo stimulation was ineffective. No side effects were observed in either real rTMS or placebo stimulation. Clinical factors including age, gender, disease duration, UPDRS score pre-rTMS, and daily dose of L-DOPA did not influence the improvement of UPDRS and apathy scores by real rTMS. Conclusions: rTMS over the SMA appears to be effective for treatment of apathy and depression in PD patients in addition to UPDRS.


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